TPDB

3D PDB MODEL

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TPDB ID TPDB41690

Activity

Anticancer

Activity_category_statistics

Cancer-related peptides

Database_Source

dbACP

Sequence_Type

standard

Has_Modification No

Description A 2240-aa standard natural anticancer peptide sequence curated from dbACP, with an available 3D structural model.

Sequence

MDSIKLTESHQGLSVLHAKQATETMRETLSSSSSPLSLSSITSPLSSASEPPALGEIQARVSESTLFSNAQVPEFWETCVHEVIQQRCREAPESSAVAAWDGSFTYSELDELSNRLASSLILLGVKAETFVPICMEKSRWATVAILGVMKAGGAFTLLDPSYPLPRLKTICEELSSLVVLSSTTQSERCTQLANVIVVEHLCRAWHPGAYLAQSPATVCPSNVLYVAFTSGSTGKPKGVLIEHRAYSTGAREHLRVFQIDQTSRVLQFSSYAFDVNIMETLSTLMAGGCLCVVGEAQRSDVSLFAEAVDELQVSHAMLTPSFARTVPWENVRHLRVLILGGEEMRESDAAICAERGVRLINAYGAAECSVNATARPGVQPGDNLSTIGHGTGAIAWIIDPDDPERQMGPGTAGELLLEGPIVGRGYLNSPDMTDRVFIDPPTWLRQLRMMDYQHQLYRTGDLAVQDSTGALTLLGRKEGQVKIRGQRVEVAEIEQHIDQVLTAATEVVVEKVTPECDQRDVLMAFVQTGRAAQGWTEGSPFFLPPRPASIQEFSAAQSQLREQLPSYMIPAIFIGVSCIPRTPSGKADRRLLRMTAARLSREELQAFAGSPVHSRPPTTATEHALQQLYADVLELPIMRISMEDSFVRLGGDSIMAVRLVGAARQAGLVLDIRDVLGTARLEEQARKATPVSEETPCEAYVPFSMLGSRCTDRDEVLRVAAEQCGTSPSEIEDIFPCTPLQEGMLALSSSQPQMYVGQIVFGMPEDVDVSQFKAAWQSTADATPILRTRIIHTPQGLLQVVLRGKLAWENYNEHPEACAADVGSQIGSPGAPLIRFALGDGDHRGEFTLTVHHAVWDAWTMRLIHDALERSFQGEMTKKHPFHPFIQYLQQVDGATMDDFWRTELADLEAPSFPALPSTQHRPSPTAMLRHTVEKIEVVPRIHTMASYIHLAWSLLVAHYTDSTEAVYGAIVSGRNSPVAAINELAGPTIATVPVRVRVSPEDTVSAALEQIQTCMVRMVPHEQAGLLRIAKASPDAARACSFQSHLNIQVVEQEHRLLPARRGIASTGMELTRFSSYALNLMLQLSPDNTSVTVDIAYDPQVLSAWEVDRMIHQWEHILRQICREPSGSLQELDFASPQDRDLLRLRNSETPTVDWRCLHDLVLAQEARQPSREAVSAWDGDFTYRELAELSSNFARLLNLFAVGRGSFVPICMDKSRWAIVSILAVLQAGATCVLLDPQHPRQRMQDTIAGLSVPVLVNAPSTAPVTKGLCAIELCVSAKLTEQLWTNAYGSRFQTHVDPDDLAFLIFTSGSTGVPKGIAMPHCTVSSSIYHNSAPMMFDADTRALHFSSYAFDVSIYEIFTTLASGGCVCVPSEFQRTNELADFIQQRAVNWTFLTPSTAQSLHPSEVPGVATLVLGGEAVTPDHVKTWAPGRSLINGYGPAEATICAVGPMPEHGWDPGNIGHVVGGVGWVTIPSDPSRLAAIGAIGELLLEGPFLARGYLNQHEATAASFISPPPWHRTLLPDCDAETTRLYRTGDLVQYEEDGSIRYIGRRDTQLKLRGQRIDLGEIETQLRRSFPGVHDVVAEAIQLPILQDRAALVAFIGCQEAQVTESAVGEQVLSAVDESFQHTVSLAQTRLQAILPPYMLPSVFFPLAHCPKTLTGKTDRRYLRQAVLALPPHELQRYRVAGRQKARIPVSRGPELRLQSIWADLLRIPCDDIGSDDTFLLHGGDSVAAMRMVALARRADFTFRVTDVLSNCTLSELARCTGEEPCLTDGDGTLPTTHEFESGHKMVDSPVSADYHTGMIGTELEMENDAIAVYPTTQAQSFLIKRYPWTHWRFSFHGEVSVERLRTACARLVAAHSIMRTLFVAGAGGERVRHVVMKELDIPLHTGTTHKNLVDYCQSICDAEQEMDVLEAVLPTRLTLISDALQTSHIFILRLSHAQYDGICVPKIFADLEALYNGTEPIAPTRFERYLDERRWYSGERARAFWKEYLAGSSPPCTMPVKATPPTDSDDSRPSAARSVISASQTVRCTAIPFQVTLATVVKAAACLVLARLTGRTDITVGQTVNGRSLPQPWVSEVVGPCVNYIPFRATLSESMSIQDYLVHMQSQHNRCIHYDGAELDTIIKNCTTWDPSTEFGFILQHQNIDMDLSLTLDGNRCASCASSGRLRPSNEVWICSTPSPSGVDLDVVASSQTLTADAAKNLVDDIADMIQTLLYNLETPLRDVVEFD

FASTA

>TPDB41690|Anticancer|length=2240
MDSIKLTESHQGLSVLHAKQATETMRETLSSSSSPLSLSSITSPLSSASEPPALGEIQARVSESTLFSNAQVPEFWETCVHEVIQQRCREAPESSAVAAWDGSFTYSELDELSNRLASSLILLGVKAETFVPICMEKSRWATVAILGVMKAGGAFTLLDPSYPLPRLKTICEELSSLVVLSSTTQSERCTQLANVIVVEHLCRAWHPGAYLAQSPATVCPSNVLYVAFTSGSTGKPKGVLIEHRAYSTGAREHLRVFQIDQTSRVLQFSSYAFDVNIMETLSTLMAGGCLCVVGEAQRSDVSLFAEAVDELQVSHAMLTPSFARTVPWENVRHLRVLILGGEEMRESDAAICAERGVRLINAYGAAECSVNATARPGVQPGDNLSTIGHGTGAIAWIIDPDDPERQMGPGTAGELLLEGPIVGRGYLNSPDMTDRVFIDPPTWLRQLRMMDYQHQLYRTGDLAVQDSTGALTLLGRKEGQVKIRGQRVEVAEIEQHIDQVLTAATEVVVEKVTPECDQRDVLMAFVQTGRAAQGWTEGSPFFLPPRPASIQEFSAAQSQLREQLPSYMIPAIFIGVSCIPRTPSGKADRRLLRMTAARLSREELQAFAGSPVHSRPPTTATEHALQQLYADVLELPIMRISMEDSFVRLGGDSIMAVRLVGAARQAGLVLDIRDVLGTARLEEQARKATPVSEETPCEAYVPFSMLGSRCTDRDEVLRVAAEQCGTSPSEIEDIFPCTPLQEGMLALSSSQPQMYVGQIVFGMPEDVDVSQFKAAWQSTADATPILRTRIIHTPQGLLQVVLRGKLAWENYNEHPEACAADVGSQIGSPGAPLIRFALGDGDHRGEFTLTVHHAVWDAWTMRLIHDALERSFQGEMTKKHPFHPFIQYLQQVDGATMDDFWRTELADLEAPSFPALPSTQHRPSPTAMLRHTVEKIEVVPRIHTMASYIHLAWSLLVAHYTDSTEAVYGAIVSGRNSPVAAINELAGPTIATVPVRVRVSPEDTVSAALEQIQTCMVRMVPHEQAGLLRIAKASPDAARACSFQSHLNIQVVEQEHRLLPARRGIASTGMELTRFSSYALNLMLQLSPDNTSVTVDIAYDPQVLSAWEVDRMIHQWEHILRQICREPSGSLQELDFASPQDRDLLRLRNSETPTVDWRCLHDLVLAQEARQPSREAVSAWDGDFTYRELAELSSNFARLLNLFAVGRGSFVPICMDKSRWAIVSILAVLQAGATCVLLDPQHPRQRMQDTIAGLSVPVLVNAPSTAPVTKGLCAIELCVSAKLTEQLWTNAYGSRFQTHVDPDDLAFLIFTSGSTGVPKGIAMPHCTVSSSIYHNSAPMMFDADTRALHFSSYAFDVSIYEIFTTLASGGCVCVPSEFQRTNELADFIQQRAVNWTFLTPSTAQSLHPSEVPGVATLVLGGEAVTPDHVKTWAPGRSLINGYGPAEATICAVGPMPEHGWDPGNIGHVVGGVGWVTIPSDPSRLAAIGAIGELLLEGPFLARGYLNQHEATAASFISPPPWHRTLLPDCDAETTRLYRTGDLVQYEEDGSIRYIGRRDTQLKLRGQRIDLGEIETQLRRSFPGVHDVVAEAIQLPILQDRAALVAFIGCQEAQVTESAVGEQVLSAVDESFQHTVSLAQTRLQAILPPYMLPSVFFPLAHCPKTLTGKTDRRYLRQAVLALPPHELQRYRVAGRQKARIPVSRGPELRLQSIWADLLRIPCDDIGSDDTFLLHGGDSVAAMRMVALARRADFTFRVTDVLSNCTLSELARCTGEEPCLTDGDGTLPTTHEFESGHKMVDSPVSADYHTGMIGTELEMENDAIAVYPTTQAQSFLIKRYPWTHWRFSFHGEVSVERLRTACARLVAAHSIMRTLFVAGAGGERVRHVVMKELDIPLHTGTTHKNLVDYCQSICDAEQEMDVLEAVLPTRLTLISDALQTSHIFILRLSHAQYDGICVPKIFADLEALYNGTEPIAPTRFERYLDERRWYSGERARAFWKEYLAGSSPPCTMPVKATPPTDSDDSRPSAARSVISASQTVRCTAIPFQVTLATVVKAAACLVLARLTGRTDITVGQTVNGRSLPQPWVSEVVGPCVNYIPFRATLSESMSIQDYLVHMQSQHNRCIHYDGAELDTIIKNCTTWDPSTEFGFILQHQNIDMDLSLTLDGNRCASCASSGRLRPSNEVWICSTPSPSGVDLDVVASSQTLTADAAKNLVDDIADMIQTLLYNLETPLRDVVEFD

Formula C10840H17124N3036O3292S102

Absent Amino Acids

Common Amino Acids L

Mass 245923.70

PI 5.24

Basic Residues 251

Acidic Residues 259

Hydrophobic Residues 922

Net Charge -68

Boman Index 444.73

Hydrophobicity -0.090

Aliphatic Index 89.58

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 254655

Absorbance 280nm 103.55

Polar Residues 583

number

216

A

149

R

41

N

120

D

50

C

139

E

109

Q

135

G

64

H

112

I

220

L

38

K

52

M

71

F

137

P

179

S

157

T

33

W

47

Y

171

V

Amino Acid Distribution

A: 216 R: 149 N: 41 D: 120 C: 50 E: 139 Q: 109 G: 135 H: 64 I: 112 L: 220 K: 38 M: 52 F: 71 P: 137 S: 179 T: 157 W: 33 Y: 47 V: 171

Length

2240

Formula

C10840H17124N3036O3292S102

Mass

245923.70

PI

5.24

Net Charge

-68

Boman Index

444.73

Hydrophobicity

-0.090

Evidence 1 Activity

Source & Reference

Database Source dbACP