TPDB

3D PDB MODEL

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TPDB ID TPDB41671

Activity

Anticancer

Activity_category_statistics

Cancer-related peptides

Database_Source

dbACP

Sequence_Type

standard

Has_Modification No

Description A 1209-aa standard natural anticancer peptide sequence curated from dbACP, with an available 3D structural model.

Sequence

MCLPEDSSPLSGHRPVPAPRVSADRTFSCFLIGGNSLVATCAELLLSHGHRVLGLVSPDAGIRDWARQRRLPALDFGPGLTERLAATPFDYLFSIANLRMLPAALLDLPRELPVNFHDGPLPRHAGLNATTWAVLEREVSHGVTWHVMTEGADEGDVLVQRPVTVTDQDTSHTLNVKCFEAGYASFAELVGLLESGAVRRTAQDLSARSYHGRFDRPAGGGFLSWDRPAALLHAAVRAADHGPYPNEFGTAKFAAGDGAVLVSGLSPLPGPSQGPPGTVLRAGEDGLVVAVADGAVRLTGLTTPMGEPLTGTGLAGYGIRPGHRLPVPGPALLAAATDAQARHLRQERHWRRRLTDLVPADLTGADSTARGGHLAVPVPVPPGAAEAAARAGLRRDQWLLAAHLAFLTRTGVEEGTDVHWRLAHPPTGHRSVDALYASFVPLRIPPVDGADMAAFGSRVVTGTDEANRRGSHPHDLWLRDPRLRDRRPSAAGLPIAVEICDDTTAPATPADGTKLLIRIPAGEDPGPCRWLVREGTYDPGTLAALAGYAAAFLTAAATAEGGRDLSGIPLGTEAQRRGAHGEAIPADDPSPDACVHQLVTRRARLRPDAPAVSGAGQTLSYAELDRRSSALAGYLRARGIGAGHLVGVFLGRSVQLPVVLLGVMKSGAAYVPLDPVYPADRIGYMLRDTALRLVVTESGLATRLPAGHGETLVLDRSWPEVESAVPEPGARVTDEQDAYVLYTSGSTGRPKGVRIGHRALTNLIRSMCRTPGVTEDDTLLAVTTVCFDIAGLELYAPLVAGGRVEVAPEQATADGPALRDLLERVRPTVMQATPATWRMLLDAGWPRGADSPVPRVLCGGEALSDDLAGRLLAHGARLWNLYGPTETTIWSAVKRVRPEEPVTLGRPIANTVFHVVDRRLRPVPPGIPGELLIGGAGVARGYLNRPELTAERFVPDVYGGGDGTVYRTGDLVRLRPDGELEYLGRLDDQVKLHGYRIEPGEVEQALGRHPGVAEAVVVVREDRPGDRRLVAYLVPRTPGLRPAELRAHLLATLPAYMVPTAFVELDAIPLTGNGKTDRRALPRPAGVLGTRTAPTDLLERAVAGIWREVLVLDAVGAEDNFFEAGGTSLLLMRLMARINAEMDASLSRVEMFMYPTVRSMTRHLRSRRSGRTGPGPAVPQSRGTRPSRTGLADLRRRRQQVRTADETGR

FASTA

>TPDB41671|Anticancer|length=1209
MCLPEDSSPLSGHRPVPAPRVSADRTFSCFLIGGNSLVATCAELLLSHGHRVLGLVSPDAGIRDWARQRRLPALDFGPGLTERLAATPFDYLFSIANLRMLPAALLDLPRELPVNFHDGPLPRHAGLNATTWAVLEREVSHGVTWHVMTEGADEGDVLVQRPVTVTDQDTSHTLNVKCFEAGYASFAELVGLLESGAVRRTAQDLSARSYHGRFDRPAGGGFLSWDRPAALLHAAVRAADHGPYPNEFGTAKFAAGDGAVLVSGLSPLPGPSQGPPGTVLRAGEDGLVVAVADGAVRLTGLTTPMGEPLTGTGLAGYGIRPGHRLPVPGPALLAAATDAQARHLRQERHWRRRLTDLVPADLTGADSTARGGHLAVPVPVPPGAAEAAARAGLRRDQWLLAAHLAFLTRTGVEEGTDVHWRLAHPPTGHRSVDALYASFVPLRIPPVDGADMAAFGSRVVTGTDEANRRGSHPHDLWLRDPRLRDRRPSAAGLPIAVEICDDTTAPATPADGTKLLIRIPAGEDPGPCRWLVREGTYDPGTLAALAGYAAAFLTAAATAEGGRDLSGIPLGTEAQRRGAHGEAIPADDPSPDACVHQLVTRRARLRPDAPAVSGAGQTLSYAELDRRSSALAGYLRARGIGAGHLVGVFLGRSVQLPVVLLGVMKSGAAYVPLDPVYPADRIGYMLRDTALRLVVTESGLATRLPAGHGETLVLDRSWPEVESAVPEPGARVTDEQDAYVLYTSGSTGRPKGVRIGHRALTNLIRSMCRTPGVTEDDTLLAVTTVCFDIAGLELYAPLVAGGRVEVAPEQATADGPALRDLLERVRPTVMQATPATWRMLLDAGWPRGADSPVPRVLCGGEALSDDLAGRLLAHGARLWNLYGPTETTIWSAVKRVRPEEPVTLGRPIANTVFHVVDRRLRPVPPGIPGELLIGGAGVARGYLNRPELTAERFVPDVYGGGDGTVYRTGDLVRLRPDGELEYLGRLDDQVKLHGYRIEPGEVEQALGRHPGVAEAVVVVREDRPGDRRLVAYLVPRTPGLRPAELRAHLLATLPAYMVPTAFVELDAIPLTGNGKTDRRALPRPAGVLGTRTAPTDLLERAVAGIWREVLVLDAVGAEDNFFEAGGTSLLLMRLMARINAEMDASLSRVEMFMYPTVRSMTRHLRSRRSGRTGPGPAVPQSRGTRPSRTGLADLRRRRQQVRTADETGR

Formula C5689H9114N1714O1671S27

Absent Amino Acids

Common Amino Acids A

Mass 129125.05

PI 7.63

Basic Residues 168

Acidic Residues 135

Hydrophobic Residues 499

Net Charge +4

Boman Index 247.16

Hydrophobicity -0.157

Aliphatic Index 90.59

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 120375

Absorbance 280nm 93.22

Polar Residues 201

number

150

A

128

R

14

N

75

D

10

C

60

E

20

Q

129

G

32

H

24

I

144

L

8

K

17

M

24

F

102

P

50

S

82

T

15

W

25

Y

100

V

Amino Acid Distribution

A: 150 R: 128 N: 14 D: 75 C: 10 E: 60 Q: 20 G: 129 H: 32 I: 24 L: 144 K: 8 M: 17 F: 24 P: 102 S: 50 T: 82 W: 15 Y: 25 V: 100

Length

1209

Formula

C5689H9114N1714O1671S27

Mass

129125.05

PI

7.63

Net Charge

+4

Boman Index

247.16

Hydrophobicity

-0.157

Evidence 1 Activity

Source & Reference

Database Source dbACP