TPDB

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB41662

Activity

Anticancer

Activity_category_statistics

Cancer-related peptides

Database_Source

dbACP

Sequence_Type

standard

Has_Modification No

Description A 594-aa standard natural anticancer peptide sequence curated from dbACP, with an available 3D structural model.

Sequence

MATLSMQVSILSKEVKNVNNIGMRASKPMVARRVSTTRLRPICSASLQVEEETRRSGNYQASIWNNDYVQSFNTNQYKDEKHLKKKEELIAQVKILLNTKMEAVKQLELIEDLRNLGLTYYFQDEVKKILTSIYNDHKCFKNEQVGDLYFTSLGFRLLRLHGFDVSEEVFDFFKNEDGSDFKASLGENIKDVLQLYEASFLIREGEVILEQARVFSTKHLEKKVDEGINDEKLLAWIRHSLALPLHWRIQRLEARWFLDAYRARKDMIPLIFELGKIDFHIIQETQLEELQEVSKWWTNSNLAEKLPFVRDRIVECYFWALGLFEPHEYGYQRKMAAIIITFVTIIDDVYDVYGTLDELQLFTDAIRKWDFQSISTLPYYMQVCYLALYTYASELAYDILKDQGFNSIAYLQRSWLSLVEGFFQEAKWYYAGYTPTLAEYLENAKVSISSPTIISQVYFTLPNSTERTVVENVFGYHNILYLSGMILRLADDLGTTQFELKRGDVQKAIQCYMKDNNATEKEGAEHVKYLLREAWKEMNTAMADPECPLSEDLVDAAANLGRASQFIYLEGDGHGVQHSEIHNQMGGLIFEPYV

FASTA

>TPDB41662|Anticancer|length=594
MATLSMQVSILSKEVKNVNNIGMRASKPMVARRVSTTRLRPICSASLQVEEETRRSGNYQASIWNNDYVQSFNTNQYKDEKHLKKKEELIAQVKILLNTKMEAVKQLELIEDLRNLGLTYYFQDEVKKILTSIYNDHKCFKNEQVGDLYFTSLGFRLLRLHGFDVSEEVFDFFKNEDGSDFKASLGENIKDVLQLYEASFLIREGEVILEQARVFSTKHLEKKVDEGINDEKLLAWIRHSLALPLHWRIQRLEARWFLDAYRARKDMIPLIFELGKIDFHIIQETQLEELQEVSKWWTNSNLAEKLPFVRDRIVECYFWALGLFEPHEYGYQRKMAAIIITFVTIIDDVYDVYGTLDELQLFTDAIRKWDFQSISTLPYYMQVCYLALYTYASELAYDILKDQGFNSIAYLQRSWLSLVEGFFQEAKWYYAGYTPTLAEYLENAKVSISSPTIISQVYFTLPNSTERTVVENVFGYHNILYLSGMILRLADDLGTTQFELKRGDVQKAIQCYMKDNNATEKEGAEHVKYLLREAWKEMNTAMADPECPLSEDLVDAAANLGRASQFIYLEGDGHGVQHSEIHNQMGGLIFEPYV

Formula C3132H4824N808O916S19

Absent Amino Acids

Common Amino Acids L

Mass 69062.76

PI 5.09

Basic Residues 78

Acidic Residues 85

Hydrophobic Residues 265

Net Charge -19

Boman Index 118.76

Hydrophobicity -0.283

Aliphatic Index 93.25

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 108555

Absorbance 280nm 157.18

Polar Residues 157

number

39

A

28

R

27

N

33

D

6

C

52

E

29

Q

28

G

13

H

39

I

67

L

37

K

13

M

29

F

13

P

35

S

28

T

11

W

32

Y

35

V

Amino Acid Distribution

A: 39 R: 28 N: 27 D: 33 C: 6 E: 52 Q: 29 G: 28 H: 13 I: 39 L: 67 K: 37 M: 13 F: 29 P: 13 S: 35 T: 28 W: 11 Y: 32 V: 35

Length

594

Formula

C3132H4824N808O916S19

Mass

69062.76

PI

5.09

Net Charge

-19

Boman Index

118.76

Hydrophobicity

-0.283

Evidence 1 Activity

Source & Reference

Database Source dbACP