TPDB

3D PDB MODEL

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TPDB ID TPDB41641

Activity

Anticancer

Activity_category_statistics

Cancer-related peptides

Database_Source

dbACP

Sequence_Type

standard

Has_Modification No

Description A 340-aa standard natural anticancer peptide sequence curated from dbACP, with an available 3D structural model.

Sequence

MAMPLRQSIKVATYLAEQKIRRRDKFPLIVELEPLFACNLACEGCGKIQHPAGVLKQRMPVAQAVGAVLESGAPMVSIAGGEPLMHPQIDEIVRQLVAKRKYVFLCTNAMLMRKKMDKFKPSPYFAFAVHIDGLRERHDESVAKEGVFDEAVEAIKEAKRRGFRVTTNSTFFNTDTPQTIVEVLNFLNDDLKVDEMMISPAYAYEKAPDQEHFLGVEQTRELFKKAFSGGNRARWRLNHSPLFLDFLEGKVDFPCTAWAIPNYSLFGWQRPCYLMSDGYVPTYRELIEKTDWDKYGRGKDPRCDNCMAHCGYEPTAVLATMGSLKESLRAMRETVSSNRE

FASTA

>TPDB41641|Anticancer|length=340
MAMPLRQSIKVATYLAEQKIRRRDKFPLIVELEPLFACNLACEGCGKIQHPAGVLKQRMPVAQAVGAVLESGAPMVSIAGGEPLMHPQIDEIVRQLVAKRKYVFLCTNAMLMRKKMDKFKPSPYFAFAVHIDGLRERHDESVAKEGVFDEAVEAIKEAKRRGFRVTTNSTFFNTDTPQTIVEVLNFLNDDLKVDEMMISPAYAYEKAPDQEHFLGVEQTRELFKKAFSGGNRARWRLNHSPLFLDFLEGKVDFPCTAWAIPNYSLFGWQRPCYLMSDGYVPTYRELIEKTDWDKYGRGKDPRCDNCMAHCGYEPTAVLATMGSLKESLRAMRETVSSNRE

Formula C1723H2701N475O492S23

Absent Amino Acids

Common Amino Acids A

Mass 38679.67

PI 8.00

Basic Residues 54

Acidic Residues 44

Hydrophobic Residues 141

Net Charge +3

Boman Index 81.18

Hydrophobicity -0.343

Aliphatic Index 75.47

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 38890

Absorbance 280nm 100.54

Polar Residues 72

number

30

A

24

R

11

N

18

D

9

C

26

E

11

Q

20

G

7

H

13

I

28

L

23

K

14

M

18

F

20

P

15

S

15

T

4

W

11

Y

23

V

Amino Acid Distribution

A: 30 R: 24 N: 11 D: 18 C: 9 E: 26 Q: 11 G: 20 H: 7 I: 13 L: 28 K: 23 M: 14 F: 18 P: 20 S: 15 T: 15 W: 4 Y: 11 V: 23

Length

340

Formula

C1723H2701N475O492S23

Mass

38679.67

PI

8.00

Net Charge

+3

Boman Index

81.18

Hydrophobicity

-0.343

Evidence 1 Activity

Source & Reference

Database Source dbACP