TPDB

3D PDB MODEL

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TPDB ID TPDB41582

Peptide_Name

LS10

Activity

Anticancer Tumor-homing Peptides

Activity_category_statistics

Cancer-related peptides

Database_Source

Peptipedia StackTHP StackTHPred TumorHoPe2.0

Sequence_Type

standard

Has_Modification No

Description A 10-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.

Sequence

LTLRWVGLMS

FASTA

>TPDB41582|Anticancer;Tumor-homing Peptides|length=10
LTLRWVGLMS

Formula C54H90N14O13S1

Absent Amino Acids ANDCEQHIKFPY

Common Amino Acids L

Mass 1175.45

PI 11.05

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 6

Net Charge +1

Boman Index -2.60

Hydrophobicity 1.020

Aliphatic Index 146.00

Half Life

Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 5500

Absorbance 280nm 467.90

Polar Residues 2

number

0

A

1

R

0

N

0

D

0

C

0

E

0

Q

1

G

0

H

0

I

3

L

0

K

1

M

0

F

0

P

1

S

1

T

1

W

0

Y

1

V

Amino Acid Distribution

A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 3 K: 0 M: 1 F: 0 P: 0 S: 1 T: 1 W: 1 Y: 0 V: 1

Length

10

Formula

C54H90N14O13S1

Mass

1175.45

PI

11.05

Net Charge

+1

Boman Index

-2.60

Hydrophobicity

1.020

Evidence 1 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Tumor cell and angiogenic tumor vasculature

Homing or Targeting Homing

Target Tumor Melanoma

Receptors Biomarker Proteoglycan

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title NG2 proteoglycan-binding peptides target tumor neovasculature

Year 1999

Reference

Burg MA et al. Cancer Res. 1999 Jun 15 59(12):2869-74.

Patent US 6,528,481 B1

Other

Source Activity Label	Source Definition
Tumor-homing Peptides	TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.

InVitro ExVivo NG2 fragments (transfected human embryonic kidney 293 cells )

InVivo Model NG2 knockout mice, NG2 expressing wild mice.

Source Type Phage display library

Phage Display Library Phage/linear 10 mer peptide library

Evidence 2 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Tumor cell

Homing or Targeting Homing

Target Tumor Glioma

Receptors Biomarker NG2

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title Glioma homing peptide-modified PEG-PCL nanoparticles for enhanced anti-glioma therapy

Year 2016

Reference

Yongbin Chi et al. J Drug Target. 2016 24(3):224-32.

Other

InVitro ExVivo U87MG glioma cells

Source Type Synthetic

Conjugate Payload poly(ethylene glycol)-poly(ɛ-caprolactone) (PEG-PCL) nanoparticles

Conjugate_Payload

poly(ethylene glycol)-poly(ɛ-caprolactone) (PEG-PCL) nanoparticles

InVitro_ExVivo

NG2 fragments (transfected human embryonic kidney 293 cells ) U87MG glioma cells

InVivo_Model

NG2 knockout mice, NG2 expressing wild mice.

Phage_Display_Library

Phage/linear 10 mer peptide library