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Peptide record

TPDB41577

p28 Anticancer Antiviral Cell-penetrating Peptides Tumor-homing Peptides standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB41577
p28
Anticancer Antiviral Cell-penetrating Peptides Tumor-homing Peptides
Anti-infective peptides Cancer-related peptides Delivery and barrier-penetrating peptides
CancerPPD 2.0 DRAVP 2.0 CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP TumorHoPe2.0
standard
No
A 28-aa standard natural multi-activity (Anticancer, Antiviral, Cell-penetrating Peptides, and other sources) peptide sequence curated from CancerPPD 2.0, DRAVP 2.0, CPPsite3.0, and other sources, with an available 3D structural model.
Sequence
LSTAADMQGVVTDGMASGLDKDYLKPDD
Physicochemical Analysis
C122H197N31O47S2
RNCEHIFW
D
2914.21
3.58
2
6
11
-4
7.51
-0.371
73.21
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
1490
51.13
6
Residue Composition
number
3
A
0
R
0
N
6
D
0
C
0
E
1
Q
3
G
0
H
0
I
3
L
2
K
2
M
0
F
1
P
2
S
2
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 3 R: 0 N: 0 D: 6 C: 0 E: 0 Q: 1 G: 3 H: 0 I: 0 L: 3 K: 2 M: 2 F: 0 P: 1 S: 2 T: 2 W: 0 Y: 1 V: 2
Chemical Descriptors
28
C122H197N31O47S2
2914.21
3.58
-4
7.51
-0.371
Free
L
Anionic Amphipathic
Linear
Linear
Free
Antitumor
Pseudomonas aeruginosa
N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(=O)N)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)O N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)NCC(=O)O
Evidence Records 7 records
Evidence 1 Activity

Activity

IC50
IC50 ~ 200 µg/ml
Anticancer
200 µg/mL

Target

Colon Cancer
HT-29
Colon

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2023

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

IC50
IC50 ~ 150 µg/ml
Anticancer
150 µg/mL

Target

Colorectal Cancer
CT-26
Colon

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2023
Evidence 3 Activity

Activity

Cell-penetrating Peptides

Target

MCF-7, p53wt, isogenic MDD2, p53dom/neg, MDA-MB-231, p53mut, MCF- 10A, p53wt, UISO-Mel-6, p53null, UISO-Mel-23, p53mut, UISO-Mel-29, p53wt

Assay & Model

Male and female athymic mice
Male and female athymic mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Anionic
Protein derived
In vitro and in vivo
CCCCCCTTGGGTGGGTTTTCCCSSSCCC
Evidence 4 Activity

Activity

Cell-penetrating Peptides

Target

MCF-7, MDA-MB-231, and T47D, HCT116 and HT29, HT1080, (HTB-88), osteosarcoma (TE85), rhabdomyosarcoma (RD), glioblastoma (U87 and LN229), neuroblastoma (SK-N-BE2), prostate cancer (DU145), pancreatic cancer (MIA-Paca2) and ovarian cancer (ES-2)]. Melanoma lines (UISO-Mel-23, 29

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Anionic
Protein derived
In vitro
CCCCCCTTGGGTGGGTTTTCCCSSSCCC
Evidence 5 Activity

Activity

Cell-penetrating Peptides

Target

A549 , Sv-5268 And Rev268 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Anionic
Protein derived
EcFbFP as a (photo-)toxic entity domain
Cytoskeleton And Cytoplasm
Intrinsic green fluorescence of the PS domain revealed an efficient uptake of the fusion protein compared to the control EcFbFP in the A549 cancer cell line over a period of 7 h revealed a fast internalization.
Clathrin and caveolae mediated endocytosis
In vitro
CCCCCCTTGGGTGGGTTTTCCCSSSCCC
Evidence 6 Activity

Activity

Cell-penetrating Peptides

Target

Hek-293T

Assay & Model

C57BL/6 female mice, 5–7 week old
C57BL/6 female mice, 5–7 week old

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Amphipathic
Fusogenic
HPV E7 oncoprotein
Transfer E7 protein into the cells
In vitro and in vivo
CTTTHHHHTTTSCSCC
Evidence 7 Activity

Activity

Tumor-homing Peptides

Target

glioblastoma
Targeting
Blood-Brain barrier

Source & Reference

TumorHoPe2.0
TumorHoPe2
Tumor-targeting cell-penetrating peptide, p28, for glioblastoma imaging and therapy
2022
Mander S et al. Front Oncol. 2022 12:940001.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
GBM LN-229, U-118
LN-229 xenograft mice
Synthetic
Gold nanoparticles
Additional Detail Fields 4 fields
Gold nanoparticles
CCCCCCTTGGGTGGGTTTTCCCSSSCCC CTTTHHHHTTTSCSCC
GBM LN-229, U-118
LN-229 xenograft mice