Back to search

Peptide record

TPDB41543

CopA3 Anticancer standard
18 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB41543
CopA3
Anticancer
Cancer-related peptides
CancerPPD 2.0
standard
No
A 18-aa standard natural anticancer peptide sequence curated from CancerPPD 2.0, with an available 3D structural model.
C-terminal: Amidation
Sequence
LLCIALRKKLLCIALRKK-NH2
Physicochemical Analysis
C96H182N28O19S2
NDEQGHMFPSTWYV
L
2096.80
10.97
6
0
10
+6
0.78
0.878
184.44
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
125
5.96
2
Residue Composition
number
2
A
2
R
0
N
0
D
2
C
0
E
0
Q
0
G
0
H
2
I
6
L
4
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 2 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 6 K: 4 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
18
C96H182N28O19S2
2096.80
10.97
+6
0.78
0.878
Amidation
L
Linear
Free
Antimicrobial
analogue derived from coprisin
Evidence Records 8 records
Evidence 1 Activity

Activity

IC50
IC50 ~ 20-50 µM
Anticancer
20-50 µM

Target

Gastric cancer
SNU-484
Stomach

Assay & Model

MTS assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2015

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

IC50
IC50 ~ 20-50 µM
Anticancer
20-50 µM

Target

Gastric cancer
SNU-601
Stomach

Assay & Model

MTS assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2015
Evidence 3 Activity

Activity

IC50
IC50 ~ 20-50 µM
Anticancer
20-50 µM

Target

Gastric cancer
SNU-638
Stomach

Assay & Model

MTS assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2015
Evidence 4 Activity

Activity

IC50
IC50 ~ 20-50 µM
Anticancer
20-50 µM

Target

Gastric cancer
SNU-668
Stomach

Assay & Model

MTS assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2015
Evidence 5 Activity

Activity

Cytotoxicity
Cytotoxicity ~ 60-80% at 50 µM
Anticancer
~60-80 % at 50 µM

Target

Gastric cancer
SNU-484
Stomach

Assay & Model

LDH release assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2015
Evidence 6 Activity

Activity

Cytotoxicity
Cytotoxicity ~ 60-80% at 50 µM
Anticancer
~60-80 % at 50 µM

Target

Gastric cancer
SNU-601
Stomach

Assay & Model

LDH release assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2015
Evidence 7 Activity

Activity

Cytotoxicity
Cytotoxicity ~ 60-80% at 50 µM
Anticancer
~60-80 % at 50 µM

Target

Gastric cancer
SNU-638
Stomach

Assay & Model

LDH release assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2015
Evidence 8 Activity

Activity

Cytotoxicity
Cytotoxicity ~ 60-80% at 50 µM
Anticancer
~60-80 % at 50 µM

Target

Gastric cancer
SNU-668
Stomach

Assay & Model

LDH release assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2015