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Peptide record

TPDB41500

Tachyplesin Anticancer standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB41500
Tachyplesin
Anticancer
Cancer-related peptides
CancerPPD 2.0
standard
No
A 18-aa standard natural anticancer peptide sequence curated from CancerPPD 2.0, with an available 3D structural model.
C-terminal: Amidation
Sequence
KWCFRVCYRGICYIRRCR-NH2
Physicochemical Analysis
C105H165N35O21S4
ANDEQHLMPST
R
2381.93
10.10
6
0
7
+6
-1.32
-0.239
59.44
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
8730
366.51
6
Residue Composition
number
0
A
5
R
0
N
0
D
4
C
0
E
0
Q
1
G
0
H
2
I
0
L
1
K
0
M
1
F
0
P
0
S
0
T
1
W
2
Y
1
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 0 C: 4 E: 0 Q: 0 G: 1 H: 0 I: 2 L: 0 K: 1 M: 0 F: 1 P: 0 S: 0 T: 0 W: 1 Y: 2 V: 1
Chemical Descriptors
18
C105H165N35O21S4
2381.93
10.10
+6
-1.32
-0.239
Amidation
L
Linear
Free
Antibacterial
Horseshoe crab
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
IC50 = 35 µg/ml
Anticancer
35 µg/mL

Target

Lung Cancer
A-549
Lung

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2021

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

IC50
IC50 = 25 µg/ml
Anticancer
25 µg/mL

Target

Lung Cancer
H-460
Lung

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2021