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Peptide record

TPDB41444

K4F6K4 Anticancer standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB41444
K4F6K4
Anticancer
Cancer-related peptides
CancerPPD 2.0
standard
No
A 14-aa standard natural anticancer peptide sequence curated from CancerPPD 2.0, with an available 3D structural model.
Sequence
KKKKFFFFFFKKKK
Physicochemical Analysis
C102H152N22O15
ARNDCEQGHILMPSTWYV
K
1926.47
11.36
8
0
6
+8
1.14
-1.029
0.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
8
K
0
M
6
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 8 M: 0 F: 6 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
14
C102H152N22O15
1926.47
11.36
+8
1.14
-1.029
Free
L
Linear
Free
Antimicrobial
Synthetic
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
IC50 = 62.64 ± 9.55 µg/mL
Anticancer
62.64

Target

Lung Cancer
A-549
Lung

Assay & Model

CCK-8 assay
48-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2022

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

apoptotic cells (early and late) increased from 9.59 ± 1.00% to 43.03 ± 2.13%
Anticancer

Target

Lung Cancer
A-549
Lung

Assay & Model

AnnexinV-FITC/PI double staining assay
12-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2022