TPDB

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB41422

Peptide_Name

CTCE-9908 (Synthetic) dimer

Activity

Anticancer Tumor-homing Peptides

Activity_category_statistics

Cancer-related peptides

Database_Source

Peptipedia StackTHP StackTHPred TumorHoPe2.0

Sequence_Type

standard

Has_Modification No

Description A 8-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.

Modification

N-terminal: Attachment of lysine for dimer formation

Sequence

KGVSLSYR

FASTA

>TPDB41422|Anticancer;Tumor-homing Peptides|length=8
KGVSLSYR

Formula C40H68N12O12

Absent Amino Acids ANDCEQHIMFPTW

Common Amino Acids S

Mass 909.05

PI 10.42

Basic Residues 2

Acidic Residues 0

Hydrophobic Residues 3

Net Charge +2

Boman Index 0.64

Hydrophobicity -0.462

Aliphatic Index 85.00

Half Life

Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 1490

Absorbance 280nm 163.91

Polar Residues 3

number

0

A

1

R

0

N

0

D

0

C

0

E

0

Q

1

G

0

H

0

I

1

L

1

K

0

M

0

F

0

P

2

S

0

T

0

W

1

Y

1

V

Amino Acid Distribution

A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 1 M: 0 F: 0 P: 0 S: 2 T: 0 W: 0 Y: 1 V: 1

Length

8

Formula

C40H68N12O12

Mass

909.05

PI

10.42

Net Charge

+2

Boman Index

0.64

Hydrophobicity

-0.462

N_terminal_Modification

Attachment of lysine for dimer formation

Evidence 1 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Endothelial cell

Homing or Targeting Homing

Target Tumor Breast cancer

Receptors Biomarker SDF-1/CXCR4 ligand/receptor pair

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title

CXCR4 peptide antagonist inhibits primary breast tumor growth, metastasis and enhances the efficacy of anti-VEGF treatment or docetaxel in a transgenic mouse model.

Year 2011

Reference

Hassan S et al. Int J Cancer. 2011 Jul 1 129(1):225-32.

Patent US 2011/011 8193A1

Other

Source Activity Label	Source Definition
Tumor-homing Peptides	TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.

InVivo Model Tansgenic mouse model for breast cancer, mouse mammary tumor virus (MMTV)-driven Polyoma Middle T Antigen (PyMT) model

Source Type Synthetic

Conjugate Payload Docetaxel or DC101 (an anti-VEGFR2 monoclonal antibody)

Comments KGVSLSYR-KNH2-KGVSLSYR

Conjugate_Payload

Docetaxel or DC101 (an anti-VEGFR2 monoclonal antibody)

InVivo_Model

Tansgenic mouse model for breast cancer, mouse mammary tumor virus (MMTV)-driven Polyoma Middle T Antigen (PyMT) model