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Peptide record

TPDB41406

F3 Anticancer Cell-penetrating Peptides Tumor-homing Peptides standard
32 amino acids
Basic Information
3D PDB MODEL
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TPDB41406
F3
Anticancer Cell-penetrating Peptides Tumor-homing Peptides
Cancer-related peptides Delivery and barrier-penetrating peptides
Peptipedia CPPsite3.0 TumorHoPe2.0
standard
No
A 32-aa standard natural multi-activity (Anticancer, Cell-penetrating Peptides, and Tumor-homing Peptides) peptide sequence curated from Peptipedia, CPPsite3.0, and TumorHoPe2.0, with an available 3D structural model.
Sequence
KDEPQRRSARLSAKPAPPKPEPKPKKAPAKKC
Physicochemical Analysis
C155H268N50O42S1
NGHIMFTWYV
KP
3536.20
10.96
11
3
6
+8
18.41
-1.806
27.81
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
4
Residue Composition
number
5
A
3
R
0
N
1
D
1
C
2
E
1
Q
0
G
0
H
0
I
1
L
8
K
0
M
0
F
8
P
2
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 5 R: 3 N: 0 D: 1 C: 1 E: 2 Q: 1 G: 0 H: 0 I: 0 L: 1 K: 8 M: 0 F: 0 P: 8 S: 2 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
32
C155H268N50O42S1
3536.20
10.96
+8
18.41
-1.806
Evidence Records 2 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Targeting
Nucleolin

Source & Reference

TumorHoPe2.0
TumorHoPe2
Modulation of hydrogel nanoparticle intracellular trafficking by multivalent surface engineering with tumor targeting peptide
2013
Leshern Karamchand et al. Nanoscale. 2013 Nov 7 5(21):10327-44.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
MDA-MB-435 human melanoma cell line, 9L rat gliosarcoma cell line
Synthetic
Polyacrylamide (PAA) hydrogel nanocarrier
Evidence 2 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Targeting
Breast cancer
Nucleolin

Source & Reference

TumorHoPe2.0
TumorHoPe2
Tumor-targeting peptide functionalized PEG-PLA micelles for efficient drug delivery
2020
Cai Y et al. Biomater Sci. 2020 Apr 15 8(8):2274-2282.

Other

-MCF 7.00
Female ICR mice (6 weeks old, 18-22 g of body weight), BALB/c mice (4-5 weeks old, 14–16 g of body weight)
Synthetic
Maleimide-Polyethylene Glycol-Polylactic Acid (mal-PEGPLA), Paclitaxel
Additional Detail Fields 3 fields
Polyacrylamide (PAA) hydrogel nanocarrier Maleimide-Polyethylene Glycol-Polylactic Acid (mal-PEGPLA), Paclitaxel
MDA-MB-435 human melanoma cell line, 9L rat gliosarcoma cell line -MCF 7.00
Female ICR mice (6 weeks old, 18-22 g of body weight), BALB/c mice (4-5 weeks old, 14–16 g of body weight)