TPDB

3D PDB MODEL

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TPDB ID TPDB41350

Peptide_Name

Clone 34 clone-2 IF7

Activity

Anticancer Tumor-homing Peptides

Activity_category_statistics

Cancer-related peptides

Database_Source

AntiCP 2.0 Peptipedia iACP-DRLF pep-lab StackTHP StackTHPred TumorHoPe2.0

Sequence_Type

standard

Has_Modification No

Description A 7-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from AntiCP 2.0, Peptipedia, iACP-DRLF, and other sources, with an available 3D structural model.

Sequence

IFLLWQR

FASTA

>TPDB41350|Anticancer;Tumor-homing Peptides|length=7
IFLLWQR

Formula C49H74N12O9

Absent Amino Acids ANDCEGHKMPSTYV

Common Amino Acids L

Mass 975.20

PI 11.05

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 5

Net Charge +1

Boman Index -3.02

Hydrophobicity 0.857

Aliphatic Index 167.14

Half Life

Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 5500

Absorbance 280nm 563.99

Polar Residues 1

number

0

A

1

R

0

N

0

D

0

C

0

E

1

Q

0

G

0

H

1

I

2

L

0

K

0

M

1

F

0

P

0

S

0

T

1

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 1 L: 2 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0

Length

7

Formula

C49H74N12O9

Mass

975.20

PI

11.05

Net Charge

+1

Boman Index

-3.02

Hydrophobicity

0.857

Evidence 1 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Homing or Targeting Targeting

Target Tumor Metastasis

Receptors Biomarker E-selectin

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title Methods for inhibiting tumor metastasis, and peptides useful therefor

Year 2008

Patent US 7,470,658 B2

Other

Source Activity Label	Source Definition
Tumor-homing Peptides	TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.

InVitro ExVivo COS 1 cell line transfected with E selectin

Source Type Phage display library

Phage Display Library T7 phage /(CX7C) peptide library

Evidence 2 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Tumor cell

Homing or Targeting Homing

Target Tumor

Lung cancer, Breast cancer, Liver cancer, Melanoma, stomach cancer, Pancreatic cancer, Colorectal cancer, Ovarian cancer, Renal cell carcinoma, Prostate cancer, Brain tumor

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title Noxa-derived, cell death-inducing peptide eMTD

Year 2022

Reference

US 11248024 B2

Patent US 11248024 B2

Other

InVitro ExVivo Sp2/0, CHO (Chinese hamster ovary) K1, CHO DG44, PER.C6, W138, BHK, COS7, 293, HepG2, Huh7, 3T3, RIN, MDCK cell line

InVivo Model 6-week-old BalB/C mice

Source Type Synthetic

Conjugate Payload necrosis-inducing peptide, Fluorescein (FAM)

Evidence 3 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Tumor vessel, Tumor cell, Endothelial cell

Homing or Targeting Homing

Target Tumor Lung cancer

Receptors Biomarker annexin 1

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title Methods and compositions related to annexin 1-binding compounds

Year 2017

Reference

US 9610359 B2

Patent US 9610359 B2

Other

InVitro ExVivo Mouse melanoma B16F1 cells

InVivo Model C57BL/6 female mice (8-10 weeks old)

Source Type Phage Display library

Phage Display Library IF7 phage

Conjugate Payload FITC

Conjugate_Payload

necrosis-inducing peptide, Fluorescein (FAM) FITC

InVitro_ExVivo

COS 1 cell line transfected with E selectin Sp2/0, CHO (Chinese hamster ovary) K1, CHO DG44, PER.C6, W138, BHK, COS7, 293, HepG2, Huh7, 3T3, RIN, MDCK cell line Mouse melanoma B16F1 cells

InVivo_Model

6-week-old BalB/C mice C57BL/6 female mice (8-10 weeks old)

Phage_Display_Library

T7 phage /(CX7C) peptide library IF7 phage