TPDB

3D PDB MODEL

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TPDB ID TPDB41349

Peptide_Name

Clone 7 clone-1

Activity

Anticancer Tumor-homing Peptides

Activity_category_statistics

Cancer-related peptides

Database_Source

Peptipedia StackTHP StackTHPred TumorHoPe2.0

Sequence_Type

standard

Has_Modification No

Description A 7-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.

Sequence

IELLQAR

FASTA

>TPDB41349|Anticancer;Tumor-homing Peptides|length=7
IELLQAR

Formula C37H67N11O11

Absent Amino Acids NDCGHKMFPSTWYV

Common Amino Acids L

Mass 842.01

PI 6.97

Basic Residues 1

Acidic Residues 1

Hydrophobic Residues 4

Net Charge -0

Boman Index 1.81

Hydrophobicity 0.343

Aliphatic Index 181.43

Half Life

Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

1

A

1

R

0

N

0

D

0

C

1

E

1

Q

0

G

0

H

1

I

2

L

0

K

0

M

0

F

0

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 1 R: 1 N: 0 D: 0 C: 0 E: 1 Q: 1 G: 0 H: 0 I: 1 L: 2 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

7

Formula

C37H67N11O11

Mass

842.01

PI

6.97

Net Charge

-0

Boman Index

1.81

Hydrophobicity

0.343

Evidence 1 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Homing or Targeting Homing

Target Tumor Melanoma

Receptors Biomarker E-selectin

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title Methods for inhibiting tumor metastasis, and peptides useful therefor

Year 2008

Patent US 7,470,658 B2

Other

Source Activity Label	Source Definition
Tumor-homing Peptides	TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.

InVitro ExVivo HL-60 Cell line

InVivo Model Mice bearing B16 cells

Source Type Phage display library

Phage Display Library T7 phage /(CX7C) peptide library

Conjugate Payload Biotin

Evidence 2 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Tumor cell

Homing or Targeting Targeting

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title

Protease inhibitor:protease sensitive expression system, composition and methods for improving the therapeutic activity and specificity of proteins delivered by bacteria

Year 2022

Reference

US 11219671 B1

Patent US 11219671 B1

Other

InVitro ExVivo HL 60 human lymphoma, B-16 mouse melanoma

InVivo Model Salmonella typhimurium

Source Type Phage display library

Phage Display Library Ph.D-7 Phage Display

Evidence 3 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Tumor vessel, Tumor cell, Endothelial cell

Homing or Targeting Homing

Target Tumor Lung cancer

Receptors Biomarker annexin 1

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title Methods and compositions related to annexin 1-binding compounds

Year 2017

Reference

US 9610359 B2

Patent US 9610359 B2

Other

InVitro ExVivo Mouse melanoma B16F1 cells

InVivo Model C57BL/6 female mice (8-10 weeks old)

Source Type Phage Display library

Phage Display Library IF7 phage

Conjugate Payload FITC

Conjugate_Payload

Biotin FITC

InVitro_ExVivo

HL-60 Cell line HL 60 human lymphoma, B-16 mouse melanoma Mouse melanoma B16F1 cells

InVivo_Model

Mice bearing B16 cells Salmonella typhimurium C57BL/6 female mice (8-10 weeks old)

Phage_Display_Library

T7 phage /(CX7C) peptide library Ph.D-7 Phage Display IF7 phage