TPDB

3D PDB MODEL

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TPDB ID TPDB41330

Peptide_Name

P155

Activity

Anticancer Tumor-homing Peptides

Activity_category_statistics

Cancer-related peptides

Database_Source

Peptipedia StackTHP StackTHPred TumorHoPe2.0

Sequence_Type

standard

Has_Modification No

Description A 12-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.

Sequence

HSFLHPWDLFDY

FASTA

>TPDB41330|Anticancer;Tumor-homing Peptides|length=12
HSFLHPWDLFDY

Formula C78H97N17O19

Absent Amino Acids ARNCEQGIKMTV

Common Amino Acids DHLF

Mass 1576.73

PI 4.93

Basic Residues 2

Acidic Residues 2

Hydrophobic Residues 6

Net Charge -2

Boman Index -1.21

Hydrophobicity -0.400

Aliphatic Index 65.00

Half Life

Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour

Extinction Coefficient Cystines 6990

Absorbance 280nm 443.32

Polar Residues 2

number

0

A

0

R

0

N

2

D

0

C

0

E

0

Q

0

G

2

H

0

I

2

L

0

K

0

M

2

F

1

P

1

S

0

T

1

W

1

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 2 C: 0 E: 0 Q: 0 G: 0 H: 2 I: 0 L: 2 K: 0 M: 0 F: 2 P: 1 S: 1 T: 0 W: 1 Y: 1 V: 0

Length

12

Formula

C78H97N17O19

Mass

1576.73

PI

4.93

Net Charge

-2

Boman Index

-1.21

Hydrophobicity

-0.400

Motif

PW

Evidence 1 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Homing or Targeting Targeting

Target Tumor Human neuroblastoma

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title Neuroblastoma tumor cell-binding peptides identified through random peptide phage display

Year 2001

Reference

Zhang J et al. Cancer Lett. 2001 Oct 10 171(2):153-64.

Other

Source Activity Label	Source Definition
Tumor-homing Peptides	TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.

InVitro ExVivo Neuroblastoma cell lines WAC

Source Type Phage display library

Phage Display Library M13 phage /12 mer peptide library

Evidence 2 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Homing or Targeting Targeting

Target Tumor Neuroblastoma and breast cancer

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title Neuroblastoma tumor cell-binding peptides identified through random peptide phage display

Year 2001

Reference

Zhang J et al. Cancer Lett. 2001 Oct 10 171(2):153-64.

Other

InVitro ExVivo Human neuroblastoma cell lines WAC-2, Human breast cancer cell line MDA-MB-435

Source Type Phage display library

Phage Display Library M13 phage /12 mer peptide library

Conjugate Payload FITC

Conjugate_Payload

FITC

InVitro_ExVivo

Neuroblastoma cell lines WAC Human neuroblastoma cell lines WAC-2, Human breast cancer cell line MDA-MB-435

Phage_Display_Library

M13 phage /12 mer peptide library