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Peptide record

TPDB41288

Anticancer Neurotoxin standard
42 amino acids
Basic Information
3D PDB MODEL
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TPDB41288
Anticancer Neurotoxin
Cancer-related peptides Toxicity and safety peptides
CancerPPD 2.0 NTxPred2
standard
No
A 42-aa standard natural multi-activity (Anticancer and Neurotoxin) peptide sequence curated from CancerPPD 2.0 and NTxPred2, with an available 3D structural model.
Sequence
GTTCYCGKTIGIYWFGKYSCPTNRGYTGSCPYFLGICCYPVD
Physicochemical Analysis
C211H301N49O59S6
AEQHM
G
4660.36
8.00
3
1
14
+2
-5.79
0.033
44.05
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
14815
317.89
20
Residue Composition
number
0
A
1
R
1
N
1
D
6
C
0
E
0
Q
7
G
0
H
3
I
1
L
2
K
0
M
2
F
3
P
2
S
5
T
1
W
6
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 1 D: 1 C: 6 E: 0 Q: 0 G: 7 H: 0 I: 3 L: 1 K: 2 M: 0 F: 2 P: 3 S: 2 T: 5 W: 1 Y: 6 V: 1
Chemical Descriptors
42
C211H301N49O59S6
4660.36
8.00
+2
-5.79
0.033
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits voltage-gated potassium and sodium channels. It potently inhibits human Kv10.1/KCNH1/EAG1 (IC(50)=1.1 uM) and Kv1.4/KCNA4, and moderately inhibits rat Kv1.3/KCNA3, human Kv1.5/KCNA5 and human Kv2.1/KCNB1. Likely to act as a gating-modifier toxin that binds to closed Kv10.1 channels and reduces their activation by shifting their voltage-dependence in the positive direction and suppressing their current amplitudes elicited by strong depolarizing pulses. On sodium channels, it blocks rat Nav1.4/SCN4A, human Nav1.5/SCN5A and displays relatively weak inhibition of mouse Nav1.6/SCN8A. {ECO:0000269|PubMed:28902151}.

Target

voltage-gated sodium channel (Nav) voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Anthopleura elegantissima (Green aggregating anemone) (Actinia elegantissima)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
Inhibits voltage-gated potassium and sodium channels. It potently inhibits human Kv10.1/KCNH1/EAG1 (IC(50)=1.1 uM) and Kv1.4/KCNA4, and moderately inhibits rat Kv1.3/KCNA3, human Kv1.5/KCNA5 and human Kv2.1/KCNB1.
Kappa-actitoxin-Ael2e (Kappa-AITX-Ael2e) (Toxin APETx4)
sea anemone
Sea anemone type 3 (BDS) potassium channel toxin family
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
Additional Detail Fields 6 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Sea anemone type 3 (BDS) potassium channel toxin family
Kappa-actitoxin-Ael2e (Kappa-AITX-Ael2e) (Toxin APETx4)
sea anemone