TPDB

3D PDB MODEL

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TPDB ID TPDB41268

Peptide_Name

Phage 27

Activity

Anticancer Tumor-homing Peptides

Activity_category_statistics

Cancer-related peptides

Database_Source

Peptipedia StackTHP StackTHPred TumorHoPe2.0

Sequence_Type

standard

Has_Modification No

Description A 12-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.

Sequence

GRRTRSSRLRNS

FASTA

>TPDB41268|Anticancer;Tumor-homing Peptides|length=12
GRRTRSSRLRNS

Formula C55H104N28O18

Absent Amino Acids ADCEQHIKMFPWYV

Common Amino Acids R

Mass 1445.61

PI 13.00

Basic Residues 5

Acidic Residues 0

Hydrophobic Residues 1

Net Charge +5

Boman Index 4.45

Hydrophobicity -2.142

Aliphatic Index 32.50

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 5

number

0

A

5

R

1

N

0

D

0

C

0

E

0

Q

1

G

0

H

0

I

1

L

0

K

0

M

0

F

0

P

3

S

1

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 5 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 0 S: 3 T: 1 W: 0 Y: 0 V: 0

Length

12

Formula

C55H104N28O18

Mass

1445.61

PI

13.00

Net Charge

+5

Boman Index

4.45

Hydrophobicity

-2.142

Evidence 1 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Tumor cell

Homing or Targeting Homing (Phage display clone)

Target Tumor Gastric cancer, Liver metastassis

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title

Phage display selection of peptides that inhibit metastasis ability of gastric cancer cells with high liver-metastatic potential

Year 2006

Reference

Hu S et al. Biochem Biophys Res Commun. 2006 Mar 24 341(4):964-72.

Other

Source Activity Label	Source Definition
Tumor-homing Peptides	TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.

InVitro ExVivo Human gastric cancer cell line XGC9811, XGC9811(liver metastatic gastric cell line) LAGS, MKN45

InVivo Model BALB/c nude mice( 4- to 5-weeks-old) bearing human gastric carcinoma cell line XGC9811 xenograft

Source Type Phage display library

Phage Display Library M13PIII phage/12 mer random peptide library

InVitro_ExVivo

Human gastric cancer cell line XGC9811, XGC9811(liver metastatic gastric cell line) LAGS, MKN45

InVivo_Model

BALB/c nude mice( 4- to 5-weeks-old) bearing human gastric carcinoma cell line XGC9811 xenograft

Phage_Display_Library

M13PIII phage/12 mer random peptide library