TPDB

3D PDB MODEL

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TPDB ID TPDB41263

Peptide_Name

Phage 5

Activity

Anticancer Tumor-homing Peptides

Activity_category_statistics

Cancer-related peptides

Database_Source

Peptipedia StackTHP StackTHPred TumorHoPe2.0

Sequence_Type

standard

Has_Modification No

Description A 12-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.

Sequence

GRRIAGPYIALE

FASTA

>TPDB41263|Anticancer;Tumor-homing Peptides|length=12
GRRIAGPYIALE

Formula C59H98N18O16

Absent Amino Acids NDCQHKMFSTWV

Common Amino Acids ARGI

Mass 1315.54

PI 9.87

Basic Residues 2

Acidic Residues 1

Hydrophobic Residues 6

Net Charge +1

Boman Index 1.65

Hydrophobicity 0.017

Aliphatic Index 114.17

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 1490

Absorbance 280nm 113.26

Polar Residues 1

number

2

A

2

R

0

N

0

D

0

C

1

E

0

Q

2

G

0

H

2

I

1

L

0

K

0

M

0

F

1

P

0

S

0

T

0

W

1

Y

0

V

Amino Acid Distribution

A: 2 R: 2 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 2 H: 0 I: 2 L: 1 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 0

Length

12

Formula

C59H98N18O16

Mass

1315.54

PI

9.87

Net Charge

+1

Boman Index

1.65

Hydrophobicity

0.017

Evidence 1 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Tumor cell

Homing or Targeting Homing (Phage display clone)

Target Tumor Gastric cancer, Liver metastassis

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title

Phage display selection of peptides that inhibit metastasis ability of gastric cancer cells with high liver-metastatic potential

Year 2006

Reference

Hu S et al. Biochem Biophys Res Commun. 2006 Mar 24 341(4):964-72.

Other

Source Activity Label	Source Definition
Tumor-homing Peptides	TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.

InVitro ExVivo Human gastric cancer cell line XGC9811, XGC9811(liver metastatic gastric cell line) LAGS, MKN45

InVivo Model BALB/c nude mice( 4- to 5-weeks-old) bearing human gastric carcinoma cell line XGC9811 xenograft

Source Type Phage display library

Phage Display Library M13PIII phage/12 mer random peptide library

InVitro_ExVivo

Human gastric cancer cell line XGC9811, XGC9811(liver metastatic gastric cell line) LAGS, MKN45

InVivo_Model

BALB/c nude mice( 4- to 5-weeks-old) bearing human gastric carcinoma cell line XGC9811 xenograft

Phage_Display_Library

M13PIII phage/12 mer random peptide library