Back to search

Peptide record

TPDB41237

Anticancer Tumor-homing Peptides standard
7 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB41237
Anticancer Tumor-homing Peptides
Cancer-related peptides
Peptipedia StackTHP StackTHPred TumorHoPe2.0
standard
No
A 7-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.
Sequence
GNGRAHA
Physicochemical Analysis
C26H43N13O9
DCEQILKMFPSTWYV
AG
681.71
11.05
2
0
2
+1
1.87
-1.200
28.57
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
2
A
1
R
1
N
0
D
0
C
0
E
0
Q
2
G
1
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 1 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 1 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
7
C26H43N13O9
681.71
11.05
+1
1.87
-1.200
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Endothelial cell
Homing
Tumor metastasis
Aminopeptidase N (CD13) and the integrin Alpha- 5 beta-3 (CD51/CD61)

Source & Reference

TumorHoPe2.0
TumorHoPe2
Infarction of tumor vessels by NGR-peptide-directed targeting of tissue factor: experimental results and first-in-man experience
2009
Bieker R et al. Blood. 2009 May 14 113(20):5019-27.
US 2007/0032419 A1

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
Human umbilical vein endothelial cell lines activated (HUVECs),human melanoma derived cell line M21 ,The human fibrosarcoma cell line HT1080,human lung cancer cell line A549 (adenocarcinoma)
Mice bearing established human adenocarcinoma (A549), melanoma (M21), and fibrosarcoma (HT1080)
Synthetic
Truncated tissue factor
Additional Detail Fields 3 fields
Truncated tissue factor
Human umbilical vein endothelial cell lines activated (HUVECs),human melanoma derived cell line M21 ,The human fibrosarcoma cell line HT1080,human lung cancer cell line A549 (adenocarcinoma)
Mice bearing established human adenocarcinoma (A549), melanoma (M21), and fibrosarcoma (HT1080)