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Peptide record

TPDB41180

hBD3-3 M2 Anticancer standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB41180
hBD3-3 M2
Anticancer
Cancer-related peptides
CancerPPD 2.0
standard
No
A 15-aa standard natural anticancer peptide sequence curated from CancerPPD 2.0, with an available 3D structural model.
Sequence
GKCSTRGRKMCRRKK
Physicochemical Analysis
C70H135N31O18S3
ANDEQHILFPWYV
RK
1795.22
11.99
8
0
1
+8
6.78
-1.933
0.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
6.96
4
Residue Composition
number
0
A
4
R
0
N
0
D
2
C
0
E
0
Q
2
G
0
H
0
I
0
L
4
K
1
M
0
F
0
P
1
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 4 M: 1 F: 0 P: 0 S: 1 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
15
C70H135N31O18S3
1795.22
11.99
+8
6.78
-1.933
Free
L
Linear
Free
Anticancer
Synthetic
Evidence Records 2 records
Evidence 1 Activity

Activity

Concentration dependent reduction in colony formation between 100 µM and 200 µM.
Anticancer

Target

Breast Cancer
MDA-MB-231
Breast

Assay & Model

Cell Proliferation assay
48-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2018
US009993519B2

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

Inhibition in growth by apoptosis as cells positive for annexin V formed 50% of test group
Anticancer

Target

Breast Cancer
MDA-MB-231
Breast

Assay & Model

Annexin V/ PI staining assay
8-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2018
US009993519B2