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Peptide record

TPDB41178

hBD3-3 SAP15 Anticancer Cell-penetrating Peptides standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB41178
hBD3-3 SAP15
Anticancer Cell-penetrating Peptides
Cancer-related peptides Delivery and barrier-penetrating peptides
CancerPPD 2.0 CPPsite3.0
standard
No
A 15-aa standard natural multi-activity (Anticancer and Cell-penetrating Peptides) peptide sequence curated from CancerPPD 2.0 and CPPsite3.0, with an available 3D structural model.
Sequence
GKCSTRGRKCCRRKK
Physicochemical Analysis
C68H131N31O18S3
ANDEQHILMFPWYV
RK
1767.17
11.46
8
0
0
+8
6.77
-1.893
0.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
7.07
5
Residue Composition
number
0
A
4
R
0
N
0
D
3
C
0
E
0
Q
2
G
0
H
0
I
0
L
4
K
0
M
0
F
0
P
1
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 3 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 4 M: 0 F: 0 P: 0 S: 1 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
15
C68H131N31O18S3
1767.17
11.46
+8
6.77
-1.893
Free
L
Cationic
Linear
Linear
Free
Anticancer
Synthetic
N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)N)C(=O)O
Evidence Records 3 records
Evidence 1 Activity

Activity

Concentration dependent reduction in colony formation between 100 µM and 200 µM.
Anticancer

Target

Breast Cancer
MDA-MB-231
Breast

Assay & Model

Cell Proliferation assay
48-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2018
US009993519B2

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

Inhibition in growth by apoptosis as cells positive for annexin V formed 50% of test group
Anticancer

Target

Breast Cancer
MDA-MB-231
Breast

Assay & Model

Annexin V/ PI staining assay
8-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2018
US009993519B2
Evidence 3 Activity

Activity

Cell-penetrating Peptides

Target

THP-1 Cells

Assay & Model

ICR mice aged 6–8 weeks
ICR mice aged 6–8 weeks

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
Biotin-tagged
Cytosol and Nucleus
Almost all SAP15 penetrated THP-1 cells and localized to the nucleus and cytoplasm, verifying its internalization.
In vitro and in vivo
CCCCCCGGGHHHHHHHTCCCCCHHHHHCSSSSSSCCSSTTHHHHHHHHHHCCCCCHHHHHHHTTSSCCSSTTCSSSCCCCCCSSSCC
Additional Detail Fields 1 fields
CCCCCCGGGHHHHHHHTCCCCCHHHHHCSSSSSSCCSSTTHHHHHHHHHHCCCCCHHHHHHHTTSSCCSSTTCSSSCCCCCCSSSCC