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Peptide record

TPDB41174

4Dap Anticancer modified_plain modified
23 amino acids
Basic Information
3D PDB MODEL
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TPDB41174
4Dap
Anticancer
Cancer-related peptides
CancerPPD 2.0
modified_plain
Yes
A 23-aa modified anticancer peptide sequence curated from CancerPPD 2.0, with an available 3D structural model.
C-terminal: Amidation Chemical: X = 2,3-Diaminopropionic Acid , Z = norleucine
Sequence
GIKXWLHSAXKFGXKFVKXIZNS-NH2
Physicochemical Analysis
C99H154N26O22
RDCEQMPTY
K
2060.47
11.00
5
0
8
+4
0.23
-0.052
67.83
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
266.93
3
Residue Composition
number
1
A
0
R
1
N
0
D
0
C
0
E
0
Q
2
G
1
H
2
I
1
L
4
K
0
M
2
F
0
P
2
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 1 I: 2 L: 1 K: 4 M: 0 F: 2 P: 0 S: 2 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
23
C99H154N26O22
2060.47
11.00
+4
0.23
-0.052
Amidation
X = 2,3-Diaminopropionic Acid , Z = norleucine
L
Linear
Free
Anticancer
Synthetic
Evidence Records 1 records
Evidence 1 Activity

Activity

EC50
EC50 = 35.7±0.7 µM
Anticancer
35.7

Target

Pancreatic Cancer
PANC-1
Pancreas

Assay & Model

WST-1 assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2019

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.