Back to search

Peptide record

TPDB41160

MEL-Pep Anticancer standard
26 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB41160
MEL-Pep
Anticancer
Cancer-related peptides
CancerPPD 2.0
standard
No
A 26-aa standard natural anticancer peptide sequence curated from CancerPPD 2.0, with an available 3D structural model.
C-terminal: Amidation
Sequence
GIGAVLKKLTTGLKALISWIKRKRQQ-NH2
Physicochemical Analysis
C133H236N40O32
NDCEHMFPY
K
2907.59
12.45
7
0
11
+7
2.88
-0.127
123.85
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
189.16
5
Residue Composition
number
2
A
2
R
0
N
0
D
0
C
0
E
2
Q
3
G
0
H
3
I
4
L
5
K
0
M
0
F
0
P
1
S
2
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 3 H: 0 I: 3 L: 4 K: 5 M: 0 F: 0 P: 0 S: 1 T: 2 W: 1 Y: 0 V: 1
Chemical Descriptors
26
C133H236N40O32
2907.59
12.45
+7
2.88
-0.127
Amidation
L
Linear
Free
Anticancer
Synthetic analog of Melittin
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
IC50 = 4.36 µM
Anticancer
4.36 µM

Target

Liver Cancer
BEL-7402/5-FU
Liver

Assay & Model

CCK-8 assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2018

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.