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Peptide record

TPDB41153

E5 Anticancer Tumor-homing Peptides standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB41153
E5
Anticancer Tumor-homing Peptides
Cancer-related peptides
CancerPPD 2.0 TumorHoPe2.0
standard
No
A 22-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from CancerPPD 2.0 and TumorHoPe2.0, with an available 3D structural model.
Sequence
GGRSFFLLRRIQGCRFRNTVDD
Physicochemical Analysis
C113H181N39O31S1
AEHKMPWY
R
2613.98
11.80
5
2
7
+3
2.82
-0.545
66.36
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
5
Residue Composition
number
0
A
5
R
1
N
2
D
1
C
0
E
1
Q
3
G
0
H
1
I
2
L
0
K
0
M
3
F
0
P
1
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 5 N: 1 D: 2 C: 1 E: 0 Q: 1 G: 3 H: 0 I: 1 L: 2 K: 0 M: 0 F: 3 P: 0 S: 1 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
22
C113H181N39O31S1
2613.98
11.80
+3
2.82
-0.545
Free
L
Linear
Free
Anticancer
Synthetic
Evidence Records 5 records
Evidence 1 Activity

Activity

60% apoptosis rate at 80 µM
Anticancer

Target

Leukemia Cancer
NB-4
Blood

Assay & Model

FITC-Annexin V/PI double staining and flow cytometry assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2014

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

>20% apoptosis rate at 80 µM
Anticancer

Target

Leukemia Cancer
HL-60
Blood

Assay & Model

FITC-Annexin V/PI double staining and flow cytometry assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2014
Evidence 3 Activity

Activity

>20% apoptosis rate at 80 µM
Anticancer

Target

Leukemia Cancer
U-937
Blood

Assay & Model

FITC-Annexin V/PI double staining and flow cytometry assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2014
Evidence 4 Activity

Activity

49% cell viability at 100 µM
Anticancer

Target

Breast Cancer
4T1
Breast

Assay & Model

CCK-8 assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2017
Evidence 5 Activity

Activity

Tumor-homing Peptides

Target

Targeting
CXCR4, CXCL12

Source & Reference

TumorHoPe2.0
TumorHoPe2
A designed peptide targeting CXCR4 displays anti-acute myelocytic leukemia activity in vitro and in vivo
2014
Li X et al. Sci Rep.2014 Oct 14:4:6610.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
Acute promyelocytic leukemia cell HL-60 and NB4, acute monocytic leukemia cell THP-1, myelomonocytic leukemia cell U937, human umbilical vein cell ea.hy926
5-week old female NOD/SCID mice
Synthetic
Additional Detail Fields 2 fields
Acute promyelocytic leukemia cell HL-60 and NB4, acute monocytic leukemia cell THP-1, myelomonocytic leukemia cell U937, human umbilical vein cell ea.hy926
5-week old female NOD/SCID mice