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Peptide record

TPDB41148

TEAM-VP Anticancer Tumor-homing Peptides standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB41148
TEAM-VP
Anticancer Tumor-homing Peptides
Cancer-related peptides
Peptipedia StackTHP StackTHPred TumorHoPe2.0
standard
No
A 10-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.
N-terminal: FITC labeling
Sequence
GGCRGDMFGC
Physicochemical Analysis
C38H59N13O13S3
ANEQHILKPSTWYV
G
1002.15
5.95
1
1
2
-0
0.24
0.010
0.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
12.47
2
Residue Composition
number
0
A
1
R
0
N
1
D
2
C
0
E
0
Q
4
G
0
H
0
I
0
L
0
K
1
M
1
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 1 C: 2 E: 0 Q: 0 G: 4 H: 0 I: 0 L: 0 K: 0 M: 1 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
10
C38H59N13O13S3
1002.15
5.95
-0
0.24
0.010
RGD
FITC labeling
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Angiogenic endothelial cells
Homing
Metastiasis in tumor
Alpha-5 beta- 3 integrins

Source & Reference

TumorHoPe2.0
TumorHoPe2
Targeted Vpr-derived peptides reach mitochondria to induce apoptosis of alphaVbeta3-expressing endothelial cells
2007
Borgne-Sanchez A et al. Cell Death Differ. 2007 Mar 14(3):422-35.
WO96/15811,US 6,458,026 B1

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
HUVEC, HMVECd, A375M, MCF-7, MDA-MB-231, HeLa, HT-29, Jurkat, CEM and fresh peripheral blood mononuclear cells (PBMC)
BALB C mice
Synthetic
FITC, Apoptic peptide
Additional Detail Fields 3 fields
FITC, Apoptic peptide
HUVEC, HMVECd, A375M, MCF-7, MDA-MB-231, HeLa, HT-29, Jurkat, CEM and fresh peripheral blood mononuclear cells (PBMC)
BALB C mice