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Peptide record

TPDB41142

MAC1/20 Anticancer Antifungal modified_plain modified
13 amino acids
Basic Information
3D PDB MODEL
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TPDB41142
MAC1/20
Anticancer Antifungal
Anti-infective peptides Cancer-related peptides
CancerPPD 2.0 Peptipedia SATPdb dbACP CAFPdb
modified_plain
Yes
A 13-aa modified multi-activity (Anticancer and Antifungal) peptide sequence curated from CancerPPD 2.0, Peptipedia, SATPdb, and other sources, with an available 3D structural model.
C-terminal: Amidation Chemical: O = Ornithine
Sequence
GFGMALOLLOOVL-NH2
Physicochemical Analysis
C50H84N10O11S1
RNDCEQHIKPSTWY
L
1033.34
6.02
0
0
8
-0
-3.68
1.931
150.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
0
I
4
L
0
K
1
M
1
F
0
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 4 K: 0 M: 1 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
13
C50H84N10O11S1
1033.34
6.02
-0
-3.68
1.931
Amidation
O = Ornithine
L
Linear
Free
Antimicrobial and Antifungal
Macropins and their analogs
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
IC50 = 10±1 µM
Anticancer
10

Target

Cervical Cancer
HeLa
Cervix

Assay & Model

MTT/MTS assay
48-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2012

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

IC50
IC50 = 35±4 µM
Anticancer
35

Target

Colon Cancer
SW
Colon

Assay & Model

MTT/MTS assay
48-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2012
Evidence 3 Activity

Activity

IC50
IC50 = 25±3 µM
Anticancer
25

Target

Leukemia Cancer
CCRF-CEM
Blood

Assay & Model

MTT/MTS assay
48-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2012