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Peptide record

TPDB41130

Anticancer Tumor-homing Peptides standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB41130
Anticancer Tumor-homing Peptides
Cancer-related peptides
Peptipedia StackTHP StackTHPred TumorHoPe2.0
standard
No
A 6-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.
N-terminal: N -terminal conjugation with IFN?â???é??
Sequence
GCNGRC
Physicochemical Analysis
C20H36N10O8S2
ADEQHILKMFPSTWYV
CG
608.69
8.30
1
0
0
+1
0.77
-0.633
0.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
20.54
3
Residue Composition
number
0
A
1
R
1
N
0
D
2
C
0
E
0
Q
2
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 1 D: 0 C: 2 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
6
C20H36N10O8S2
608.69
8.30
+1
0.77
-0.633
NGR
N -terminal conjugation with IFN?â???é??
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Angiogenic vessels
Homing
Multiple tumor
CD13 (aminopeptidase N)

Source & Reference

TumorHoPe2.0
TumorHoPe2
Targeted delivery of IFNgamma to tumor vessels uncouples antitumor from counterregulatory mechanisms
2005
Curnis F et al. Cancer Res. 2005 Apr 1 65(7):2906-13.
WO06067633A2

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
EA.hy926 cells (human endothelial cells fused with human lung carcinoma A549 cells
Tumor-bearing C57BL6 (RMA) or BALB/c (WEHI-164) mice
Phage display library
IFNgamma
Additional Detail Fields 3 fields
IFNgamma
EA.hy926 cells (human endothelial cells fused with human lung carcinoma A549 cells
Tumor-bearing C57BL6 (RMA) or BALB/c (WEHI-164) mice