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Peptide record

TPDB41125

MPG N-Ter (MPG) Anticancer Cell-penetrating Peptides standard
27 amino acids
Basic Information
3D PDB MODEL
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TPDB41125
MPG N-Ter (MPG)
Anticancer Cell-penetrating Peptides
Cancer-related peptides Delivery and barrier-penetrating peptides
CancerPPD 2.0 CellPPD CellPPD-MOD CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 27-aa standard natural multi-activity (Anticancer and Cell-penetrating Peptides) peptide sequence curated from CancerPPD 2.0, CellPPD, CellPPD-MOD, and other sources, with an available 3D structural model.
Sequence
GALFLGFLGAAGSTMGAWSQPKKKRKV
Physicochemical Analysis
C129H208N36O32S1
NDCEHIY
G
2807.35
11.80
5
0
12
+5
-0.38
-0.004
68.89
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
195.91
4
Residue Composition
number
4
A
1
R
0
N
0
D
0
C
0
E
1
Q
5
G
0
H
0
I
3
L
4
K
1
M
2
F
1
P
2
S
1
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 4 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 5 H: 0 I: 0 L: 3 K: 4 M: 1 F: 2 P: 1 S: 2 T: 1 W: 1 Y: 0 V: 1
Chemical Descriptors
27
C129H208N36O32S1
2807.35
11.80
+5
-0.38
-0.004
Free
L
Amphipathic
Linear
Free
NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)O N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 8 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Assay & Model

Inbred C57BL/6 female mice, 5–7 week
Inbred C57BL/6 female mice, 5–7 week

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Chimeric
pcDNA-E7 plasmid
In vivo
CCCBTTBCCCCSSCCCCCCCSSCCCCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

Vero Cells And Hk-2 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Copper/zinc superoxide dismutase (SOD1)
In vitro
CCCBTTBCCCCSSCCCCCCCSSCCCCC
Evidence 3 Activity

Activity

Cell-penetrating Peptides

Target

Hek-293T

Assay & Model

C57BL/6 female mice, 5–7 week old
C57BL/6 female mice, 5–7 week old

Source & Reference

CPPsite3.0
CPPsite3

Other

Non-natural residues Linear L Amphipathic
Fusogenic
E7 DNA
Facilitate the uptake of pcDNA-E7
In vitro and in vivo
Evidence 4 Activity

Activity

Cell-penetrating Peptides

Target

Hek-293T Cells

Assay & Model

6 to 7 week-old female BALB/c mice
6 to 7 week-old female BALB/c mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Amphipathic
Protein derived
DNA (Nef DNA, Hsp20-Nef DNA)
Effectively delivered DNA
In vitro and in vivo
CCCCCSCCCC
Evidence 5 Activity

Activity

Cell-penetrating Peptides

Target

Hek-293 T Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Amphipathic
Protein derived
pEGFP-nef-vpr-gp160-p24
Cellular uptake of 20.65 ± 1.70%
In vitro
CCCCCCCCC
Evidence 6 Activity

Activity

Cell-penetrating Peptides

Assay & Model

Six to eight-week-old female BALB/c mice
Six to eight-week-old female BALB/c mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Amphipathic
Protein derived
In vivo
CCCGGGGCCCCCSSCC
Evidence 7 Activity

Activity

Cell-penetrating Peptides

Target

3T3-L1 Cell

Source & Reference

CPPsite3.0
CPPsite3

Other

Non-natural residues Linear L Amphipathic
Protein derived
miRNA-27a Nanoparticle
Cytoplasm
Uptake was relatively fast
Endocytosis and direct penetration
In vitro
Evidence 8 Activity

Activity

Cell-penetrating Peptides

Target

HeLa cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Fusogenic
PLGA NPs
Cytosol
Greatest cell internalization at both low and high density of Av-EB1, Av-MPG, and Av-MPGΔNLS NPs.
Clathrin mediated endocytosis
In vitro
CCCSCCCCCC
Additional Detail Fields 1 fields
CCCBTTBCCCCSSCCCCCCCSSCCCCC CCCCCSCCCC CCCCCCCCC CCCGGGGCCCCCSSCC CCCSCCCCCC