TPDB

3D PDB MODEL

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Standard-residue backbone model; source-recorded chemical modifications are not verified in these coordinates.

TPDB ID TPDB41122

Peptide_Name

DC1

Activity

Anticancer Antifungal

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

CancerPPD 2.0 Peptipedia dbACP Antifungipept

Sequence_Type

modified_plain

Has_Modification Yes

Description A 32-aa modified multi-activity (Anticancer and Antifungal) peptide sequence curated from CancerPPD 2.0, Peptipedia, dbACP, and other sources, with an available 3D structural model.

Modification

C-terminal: Cyclized N-terminal: Cyclized

Sequence

GAFLKCGESCVYLPCLTTVVGCSCQNSVCYRD

FASTA

>TPDB41122|Anticancer;Antifungal|length=32
GAFLKCGESCVYLPCLTTVVGCSCQNSVCYRD

Sequence-only estimates are not provided for modified or non-standard source notation. Reported molecular properties, when available, are retained below with their source records.

Length

32 reviewed residue count

C_terminal_Modification

Cyclized Activity

Chirality

L Activity

Linear_or_Cyclic

Cyclic Activity

N_terminal_Modification

Cyclized Activity

Nature

Anticancer Activity

Origin

Hedyotis diffusa Activity

Evidence 1 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 5.03 µM

Detail Source Activity Anticancer

Activity Measurement 5.03 µM

Target

Cancer Type Prostate Cancer

Cell Line LNCaP

Tissue Affected Prostate

Assay & Model

Assay CCK-8 assay

Testing Time 72-h

Source & Reference

Database Source CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2015

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 2 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 2.24 µM

Detail Source Activity Anticancer

Activity Measurement 2.24 µM

Target

Cancer Type Prostate Cancer

Cell Line PC-3

Tissue Affected Prostate

Assay & Model

Assay CCK-8 assay

Testing Time 72-h

Source & Reference

Database Source CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2015

Evidence 3 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 3.32 µM

Detail Source Activity Anticancer

Activity Measurement 3.32 µM

Target

Cancer Type Liver Cancer

Cell Line DU-145

Tissue Affected Liver

Assay & Model

Assay CCK-8 assay

Testing Time 72-h

Source & Reference

Database Source CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2015