Back to search

Peptide record

TPDB41120

LL-37 Analogue 4 Anticancer modified_plain modified
13 amino acids
Basic Information
TPDB41120
LL-37 Analogue 4
Anticancer
Cancer-related peptides
CancerPPD 2.0
modified_plain
Yes
A 13-aa modified anticancer peptide sequence curated from CancerPPD 2.0, without an available 3D structural model.
C-terminal: Amidation N-terminal: Acetylation
Sequence
Ac-FΚRIVQRILDFLR-NH2
Physicochemical Analysis
C74H122N22O16
ANCEGHKMPSTWY
R
1575.92
12.10
3
1
7
+2
0.31
0.454
142.31
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
3
R
0
N
1
D
0
C
0
E
1
Q
0
G
0
H
2
I
2
L
0
K
0
M
2
F
0
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 1 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 2 L: 2 K: 0 M: 0 F: 2 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
13
C74H122N22O16
1575.92
12.10
+2
0.31
0.454
Amidation
L
Linear
Acetylation
Antimicrobial and Anticancer
Synthetic Analog of LL-37
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
IC50 = 3.9 µg/mL
Anticancer
3.9 µg/mL

Target

Lung Cancer
A-549
Lung

Assay & Model

MTT assay
48-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2020

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.