TPDB

3D PDB MODEL

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TPDB ID TPDB41107

Peptide_Name

Clone 12 clone-6

Activity

Anticancer Tumor-homing Peptides

Activity_category_statistics

Cancer-related peptides

Database_Source

Peptipedia StackTHP StackTHPred TumorHoPe2.0

Sequence_Type

standard

Has_Modification No

Description A 7-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.

Sequence

FSLLDAR

FASTA

>TPDB41107|Anticancer;Tumor-homing Peptides|length=7
FSLLDAR

Formula C37H60N10O11

Absent Amino Acids NCEQGHIKMPTWYV

Common Amino Acids L

Mass 820.94

PI 6.78

Basic Residues 1

Acidic Residues 1

Hydrophobic Residues 4

Net Charge -0

Boman Index -0.25

Hydrophobicity 0.486

Aliphatic Index 125.71

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

1

A

1

R

0

N

1

D

0

C

0

E

0

Q

0

G

0

H

0

I

2

L

0

K

0

M

1

F

0

P

1

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 1 R: 1 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 2 K: 0 M: 0 F: 1 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 0

Length

7

Formula

C37H60N10O11

Mass

820.94

PI

6.78

Net Charge

-0

Boman Index

-0.25

Hydrophobicity

0.486

Evidence 1 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Homing or Targeting Targeting

Target Tumor Metastasis

Receptors Biomarker E-selectin

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title Methods for inhibiting tumor metastasis, and peptides useful therefor

Year 2008

Patent US 7,470,658 B2

Other

Source Activity Label	Source Definition
Tumor-homing Peptides	TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.

InVitro ExVivo COS 1 cell line transfected with E selectin

Source Type Phage display library

Phage Display Library T7 phage /(CX7C) peptide library

Evidence 2 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Tumor vessel, Tumor cell, Endothelial cell

Homing or Targeting Homing

Target Tumor Lung cancer

Receptors Biomarker annexin 1

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title Methods and compositions related to annexin 1-binding compounds

Year 2017

Reference

US 9610359 B2

Patent US 9610359 B2

Other

InVitro ExVivo Mouse melanoma B16F1 cells

InVivo Model C57BL/6 female mice (8-10 weeks old)

Source Type Phage Display library

Phage Display Library IF7 phage

Conjugate Payload FITC

Conjugate_Payload

FITC

InVitro_ExVivo

COS 1 cell line transfected with E selectin Mouse melanoma B16F1 cells

InVivo_Model

C57BL/6 female mice (8-10 weeks old)

Phage_Display_Library

T7 phage /(CX7C) peptide library IF7 phage