TPDB

3D PDB MODEL

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TPDB ID TPDB41100

Peptide_Name

DUP-1

Activity

Anticancer Tumor-homing Peptides

Activity_category_statistics

Cancer-related peptides

Database_Source

Peptipedia StackTHP StackTHPred TumorHoPe2.0

Sequence_Type

standard

Has_Modification No

Description A 12-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.

Sequence

FRPNRAQDYNTN

FASTA

>TPDB41100|Anticancer;Tumor-homing Peptides|length=12
FRPNRAQDYNTN

Formula C63H94N22O21

Absent Amino Acids CEGHILKMSWV

Common Amino Acids N

Mass 1495.57

PI 9.87

Basic Residues 2

Acidic Residues 1

Hydrophobic Residues 3

Net Charge +1

Boman Index 3.04

Hydrophobicity -2.125

Aliphatic Index 8.33

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 1490

Absorbance 280nm 99.63

Polar Residues 6

number

1

A

2

R

3

N

1

D

0

C

0

E

1

Q

0

G

0

H

0

I

0

L

0

K

0

M

1

F

1

P

0

S

1

T

0

W

1

Y

0

V

Amino Acid Distribution

A: 1 R: 2 N: 3 D: 1 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 1 S: 0 T: 1 W: 0 Y: 1 V: 0

Length

12

Formula

C63H94N22O21

Mass

1495.57

PI

9.87

Net Charge

+1

Boman Index

3.04

Hydrophobicity

-2.125

Evidence 1 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Tumor cell

Homing or Targeting Homing

Target Tumor

Lung cancer, Breast cancer, Liver cancer, Melanoma, stomach cancer, Pancreatic cancer, Colorectal cancer, Ovarian cancer, Renal cell carcinoma, Prostate cancer, Brain tumor

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title Noxa-derived, cell death-inducing peptide eMTD

Year 2022

Reference

US 11248024 B2

Patent US 11248024 B2

Other

Source Activity Label	Source Definition
Tumor-homing Peptides	TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.

InVitro ExVivo Sp2/0, CHO (Chinese hamster ovary) K1, CHO DG44, PER.C6, W138, BHK, COS7, 293, HepG2, Huh7, 3T3, RIN, MDCK cell line

InVivo Model 6-week-old BalB/C mice

Source Type Synthetic

Conjugate Payload necrosis-inducing peptide, Fluorescein (FAM)

Evidence 2 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Tumor cell

Homing or Targeting Targeting

Target Tumor Prostate cancer

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title

Protease inhibitor:protease sensitive expression system, composition and methods for improving the therapeutic activity and specificity of proteins delivered by bacteria

Year 2022

Reference

US 11219671 B1

Patent US 11219671 B1

Other

InVivo Model Salmonella typhimurium

Source Type Phage display library

Phage Display Library Ph.D-7 Phage Display

Conjugate_Payload

necrosis-inducing peptide, Fluorescein (FAM)

InVitro_ExVivo

Sp2/0, CHO (Chinese hamster ovary) K1, CHO DG44, PER.C6, W138, BHK, COS7, 293, HepG2, Huh7, 3T3, RIN, MDCK cell line

InVivo_Model

6-week-old BalB/C mice Salmonella typhimurium

Phage_Display_Library

Ph.D-7 Phage Display