TPDB

3D PDB MODEL

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TPDB ID TPDB41097

Peptide_Name

Synthetic peptide HCBP1

Activity

Anticancer Tumor-homing Peptides

Activity_category_statistics

Cancer-related peptides

Database_Source

Peptipedia StackTHP StackTHPred TumorHoPe2.0

Sequence_Type

standard

Has_Modification No

Description A 7-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.

Sequence

FQHPSFI

FASTA

>TPDB41097|Anticancer;Tumor-homing Peptides|length=7
FQHPSFI

Formula C43H58N10O10

Absent Amino Acids ARNDCEGLKMTWYV

Common Amino Acids F

Mass 874.99

PI 7.85

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 3

Net Charge +0

Boman Index -0.45

Hydrophobicity 0.143

Aliphatic Index 55.71

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 2

number

0

A

0

R

0

N

0

D

0

C

0

E

1

Q

0

G

1

H

1

I

0

L

0

K

0

M

2

F

1

P

1

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 1 I: 1 L: 0 K: 0 M: 0 F: 2 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 0

Length

7

Formula

C43H58N10O10

Mass

874.99

PI

7.85

Net Charge

+0

Boman Index

-0.45

Hydrophobicity

0.143

Evidence 1 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Tumor cell

Homing or Targeting Homing

Target Tumor Hepatoma cancer

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title Screening and identification of a targeting peptide to hepatocarcinoma from a phage display peptide library

Year 2007

Reference

Zhang B et al. Mol Med. 2007 May-Jun 13(5-6):246-54.

Other

Source Activity Label	Source Definition
Tumor-homing Peptides	TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.

InVitro ExVivo

Hepatocellular carcinoma cell line (HepG2),Hepatocellular carcinoma cell line (HepG2),Normal hepatocyte line (L-02) ,The hepatocellular carcinoma cell lines and BEL-7402, Passage cell line of human cervical cancer Hela,Human patients biopsies

InVivo Model Balb-c mice bearing HepG2 xenografts

Source Type Phage display library

Phage Display Library M13 phage /7- mer peptide library

Conjugate Payload FITC

Conjugate_Payload

FITC

InVitro_ExVivo

Hepatocellular carcinoma cell line (HepG2),Hepatocellular carcinoma cell line (HepG2),Normal hepatocyte line (L-02) ,The hepatocellular carcinoma cell lines and BEL-7402, Passage cell line of human cervical cancer Hela,Human patients biopsies

InVivo_Model

Balb-c mice bearing HepG2 xenografts

Phage_Display_Library

M13 phage /7- mer peptide library