TPDB

3D PDB MODEL

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TPDB ID TPDB41080

Peptide_Name

Crabrolin-4K

Activity

Anticancer

Activity_category_statistics

Cancer-related peptides

Database_Source

CancerPPD 2.0

Sequence_Type

standard

Has_Modification No

Description A 13-aa standard natural anticancer peptide sequence curated from CancerPPD 2.0, with an available 3D structural model.

Modification

C-terminal: Amidation

Sequence

FLPKILRKIVTAL-NH2

FASTA

>TPDB41080|Anticancer|length=13
FLPKILRKIVTAL-NH2

Formula C74H130N18O15

Absent Amino Acids NDCEQGHMSWY

Common Amino Acids L

Mass 1511.96

PI 11.64

Basic Residues 3

Acidic Residues 0

Hydrophobic Residues 8

Net Charge +3

Boman Index -0.15

Hydrophobicity 1.123

Aliphatic Index 180.00

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

1

A

1

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

2

I

3

L

2

K

0

M

1

F

1

P

0

S

1

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 1 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 3 K: 2 M: 0 F: 1 P: 1 S: 0 T: 1 W: 0 Y: 0 V: 1

Length

13

Formula

C74H130N18O15

Mass

1511.96

PI

11.64

Net Charge

+3

Boman Index

-0.15

Hydrophobicity

1.123

C_terminal_Modification

Amidation

Chirality

L

Linear_or_Cyclic

Linear

N_terminal_Modification

Free

Nature

Antimicrobial

Origin

Synthetic Analog of Crabrolin

Evidence 1 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 22.55 µM

Detail Source Activity Anticancer

Activity Measurement 22.55 µM

Target

Cancer Type Lung Cancer

Cell Line H-838

Tissue Affected Lung

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2023

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 2 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 20.58 µM

Detail Source Activity Anticancer

Activity Measurement 20.58 µM

Target

Cancer Type Prostate Cancer

Cell Line PC-3

Tissue Affected Prostate

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2023

Evidence 3 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 23.51 µM

Detail Source Activity Anticancer

Activity Measurement 23.51 µM

Target

Cancer Type Brain Tumor

Cell Line U-251-MG

Tissue Affected Brain

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2023

Evidence 4 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 42.88 µM

Detail Source Activity Anticancer

Activity Measurement 42.88 µM

Target

Cancer Type Colon Cancer

Cell Line HCT-116

Tissue Affected Colon

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2023

Evidence 5 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 23.18 µM

Detail Source Activity Anticancer

Activity Measurement 23.18 µM

Target

Cancer Type Breast Cancer

Cell Line MCF-7

Tissue Affected Breast

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2023