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Peptide record

TPDB41066

LL-37 Analogue 5 Anticancer standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB41066
LL-37 Analogue 5
Anticancer
Cancer-related peptides
CancerPPD 2.0
standard
No
A 15-aa standard natural anticancer peptide sequence curated from CancerPPD 2.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Acetylation
Sequence
Ac-FKSARIVQRILDFLR-NH2
Physicochemical Analysis
C86H144N26O20
NCEGHMPTWY
R
1862.25
12.12
4
1
8
+3
1.26
0.200
130.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
2
Residue Composition
number
1
A
3
R
0
N
1
D
0
C
0
E
1
Q
0
G
0
H
2
I
2
L
1
K
0
M
2
F
0
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 3 N: 0 D: 1 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 2 L: 2 K: 1 M: 0 F: 2 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
15
C86H144N26O20
1862.25
12.12
+3
1.26
0.200
Amidation
L
Linear
Acetylation
Antimicrobial and Anticancer
Synthetic Analog of LL-37
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
IC50 = 10.7 µg/mL
Anticancer
10.7 µg/mL

Target

Lung Cancer
A-549
Lung

Assay & Model

MTT assay
48-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2020

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.