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Peptide record

TPDB41050

LCP-1 Anticancer standard
4 amino acids
Basic Information
3D PDB MODEL
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TPDB41050
LCP-1
Anticancer
Cancer-related peptides
CancerPPD 2.0
standard
No
A 4-aa standard natural anticancer peptide sequence curated from CancerPPD 2.0, with an available 3D structural model.
C-terminal: Cyclized N-terminal: Cyclized
Sequence
FHVL
Physicochemical Analysis
C26H38N6O5
ARNDCEQGIKMPSTWY
HLFV
514.62
7.85
1
0
3
+0
-0.66
1.900
170.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
1
H
0
I
1
L
0
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 1 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
4
C26H38N6O5
514.62
7.85
+0
-0.66
1.900
Cyclized
L
Cyclic
Cyclized
Anticancer
Laminaria japonica
Evidence Records 4 records
Evidence 1 Activity

Activity

IC50
IC50 = 111 ± 10.6 µM
Anticancer
111

Target

Gastric Cancer
SGC-7901
Stomach

Assay & Model

MTT assay
48-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2021

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

IC50
IC50 = 128 ± 13.5 µM
Anticancer
128

Target

Gastric Cancer
MKN-45
Stomach

Assay & Model

MTT assay
48-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2021
Evidence 3 Activity

Activity

IC50
IC50 = 123 ± 12.9 µM
Anticancer
123

Target

Gastric Cancer
HepG-2
Stomach

Assay & Model

MTT assay
48-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2021
Evidence 4 Activity

Activity

IC50
IC50 = 131 ± 13.4 µM
Anticancer
131

Target

Colon Cancer
CaCo-2
Colon

Assay & Model

MTT assay
48-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2021