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Peptide record

TPDB41046

ACE inhibitor from alpha s1-casein ACE inhibitors Anticancer Antihypertensive Neuropeptide iDPPIV standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB41046
ACE inhibitor from alpha s1-casein
ACE inhibitors Anticancer Antihypertensive Neuropeptide iDPPIV
Cardiometabolic peptides Cancer-related peptides Neuroactive peptides
pep-lab Peptipedia AHTPDB AHTpin iDPPIV
standard
No
A 12-aa standard natural multi-activity (ACE inhibitors, Anticancer, Antihypertensive, and other sources) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
FFVAPFPEVFGK
Physicochemical Analysis
C72H97N13O15
RNDCQHILMSTWY
F
1384.64
6.94
1
1
7
-0
-0.63
0.867
56.67
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
1
E
0
Q
1
G
0
H
0
I
0
L
1
K
0
M
4
F
2
P
0
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 1 M: 0 F: 4 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
12
C72H97N13O15
1384.64
6.94
-0
-0.63
0.867
1384.6148
1383.7204
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
18.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Tauzin J., Miclo L., Gaillard J-L.
Angiotensin-I-converting enzyme inhibitory peptides from tryptic hydrolysate of bovine alpha s2-casein. FEBS Lett., 531, 369-374, 2002
2002
Journal

Other

12
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=CC=C(C=C1))C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)O InChI=1S/C72H97N13O15/c1-43(2)60(83-65(92)54(40-48-26-14-8-15-27-48)79-62(89)50(74)38-46-22-10-6-11-23-46)68(95)76-45(5)70(97)84-36-20-31-56(84)67(94)81-55(41-49-28-16-9-17-29-49)71(98)85-37-21-32-57(85)66(93)78-51(33-34-59(87)88)64(91)82-61(44(3)4)69(96)80-53(39-47-24-12-7-13-25-47)63(90)75-42-58(86)77-52(72(99)100)30-18-19-35-73/h6-17,22-29,43-45,50-57,60-61H,18-21,30-42,73-74H2,1-5H3,(H,75,90)(H,76,95)(H,77,86)(H,78,93)(H,79,89)(H,80,96)(H,81,94)(H,82,91)(H,83,92)(H,87,88)(H,99,100)/t45-,50-,51-,52-,53-,54-,55-,56-,57-,60-,61-/m0/s1 InChIKey: ILZZTQYNTRWQSJ-QUXGTSCRSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Peptide has been obtained by trypsin digestion. Anticancer peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8311) Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 380) the EROP-Moscow database Predicted antithrombotic peptide according to the BIOPEP-UWM Virtual database (ID 209) the DFBP database
Evidence 2 Activity

Activity

IC50
Antihypertensive
18.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Tauzin J., Miclo L., Gaillard J-L.
Angiotensin-I-converting enzyme inhibitory peptides from tryptic hydrolysate of bovine alpha s2-casein. FEBS Lett., 531, 369-374, 2002
2002
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
12
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=CC=C(C=C1))C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)O InChI=1S/C72H97N13O15/c1-43(2)60(83-65(92)54(40-48-26-14-8-15-27-48)79-62(89)50(74)38-46-22-10-6-11-23-46)68(95)76-45(5)70(97)84-36-20-31-56(84)67(94)81-55(41-49-28-16-9-17-29-49)71(98)85-37-21-32-57(85)66(93)78-51(33-34-59(87)88)64(91)82-61(44(3)4)69(96)80-53(39-47-24-12-7-13-25-47)63(90)75-42-58(86)77-52(72(99)100)30-18-19-35-73/h6-17,22-29,43-45,50-57,60-61H,18-21,30-42,73-74H2,1-5H3,(H,75,90)(H,76,95)(H,77,86)(H,78,93)(H,79,89)(H,80,96)(H,81,94)(H,82,91)(H,83,92)(H,87,88)(H,99,100)/t45-,50-,51-,52-,53-,54-,55-,56-,57-,60-,61-/m0/s1 InChIKey: ILZZTQYNTRWQSJ-QUXGTSCRSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Peptide has been obtained by trypsin digestion. Anticancer peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8311) Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 380) the EROP-Moscow database Predicted antithrombotic peptide according to the BIOPEP-UWM Virtual database (ID 209) the DFBP database
Additional Detail Fields 1 fields
12