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Peptide record

TPDB41018

HB43-mut2 Anticancer standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB41018
HB43-mut2
Anticancer
Cancer-related peptides
CancerPPD 2.0
standard
No
A 13-aa standard natural anticancer peptide sequence curated from CancerPPD 2.0, with an available 3D structural model.
C-terminal: Amidation
Sequence
FAKLLAKLAKLLK-NH2
Physicochemical Analysis
C72H129N17O14
RNDCEQGHIMPSTWYV
L
1456.92
11.00
4
0
9
+4
-0.48
0.892
173.08
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
3
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
5
L
4
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 5 K: 4 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
13
C72H129N17O14
1456.92
11.00
+4
-0.48
0.892
Amidation
L
Linear
Free
Anticancer
Synthetic
Evidence Records 4 records
Evidence 1 Activity

Activity

IC50
IC50 = 34 ± 2 µM
Anticancer
34

Target

Colon Cancer
SW-480
Colon

Assay & Model

AlamarBlue assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2022

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

IC50
IC50 = 40 ± 3 µM
Anticancer
40

Target

Colon Cancer
SW-620
Colon

Assay & Model

AlamarBlue assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2022
Evidence 3 Activity

Activity

IC50
IC50 = 50 ± 3 µM
Anticancer
50

Target

Colon Cancer
HT-29
Colon

Assay & Model

AlamarBlue assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2022
Evidence 4 Activity

Activity

80% cell viability at 20 µM
Anticancer

Target

Breast Cancer
MDA-MB-231
Breast

Assay & Model

AlamarBlue assay
Not Available

Source & Reference

CancerPPD 2.0
CancerPPD2
2022