TPDB

3D PDB MODEL

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TPDB ID TPDB41005

Peptide_Name

FLAK50 Z2

Activity

Anticancer

Activity_category_statistics

Cancer-related peptides

Database_Source

AntiCP 2.0 CancerPPD 2.0 Peptipedia SATPdb iACP-DRLF

Sequence_Type

standard

Has_Modification No

Description A 15-aa standard natural anticancer peptide sequence curated from AntiCP 2.0, CancerPPD 2.0, Peptipedia, and other sources, with an available 3D structural model.

Modification

C-terminal: Amidation

Sequence

FAFGKGIGKVGKKLL-NH2

FASTA

>TPDB41005|Anticancer|length=15
FAFGKGIGKVGKKLL-NH2

Formula C76H127N19O16

Absent Amino Acids RNDCEQHMPSTWY

Common Amino Acids GK

Mass 1562.96

PI 11.00

Basic Residues 4

Acidic Residues 0

Hydrophobic Residues 7

Net Charge +4

Boman Index 0.21

Hydrophobicity 0.433

Aliphatic Index 104.00

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

1

A

0

R

0

N

0

D

0

C

0

E

0

Q

4

G

0

H

1

I

2

L

4

K

0

M

2

F

0

P

0

S

0

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 4 H: 0 I: 1 L: 2 K: 4 M: 0 F: 2 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1

Length

15

Formula

C76H127N19O16

Mass

1562.96

PI

11.00

Net Charge

+4

Boman Index

0.21

Hydrophobicity

0.433

C_terminal_Modification

Amidation

Chirality

L

Linear_or_Cyclic

Linear

N_terminal_Modification

Free

Nature

Anticancer

Origin

FLAK peptides

Evidence 1 Activity

Activity

Activity Endpoint LD50

Activity Raw

LD50 =>1000 µg/ml

Detail Source Activity Anticancer

Activity Measurement >1000 µg/mL

Target

Cancer Type Breast Cancer

Cell Line MCF-7

Tissue Affected Breast

Assay & Model

Assay MTT/MTS assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0 SATPdb

Source CancerPPD2

Year 2005

Patents US_06875744_B2

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 2 Activity

Activity

Activity Endpoint LD50

Activity Raw

LD50 =>1000 µg/ml

Detail Source Activity Anticancer

Activity Measurement >1000 µg/mL

Target

Cancer Type Colon Cancer

Cell Line SW-480

Tissue Affected Colon

Assay & Model

Assay MTT/MTS assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0 SATPdb

Source CancerPPD2

Year 2005

Patents US_06875744_B2

Evidence 3 Activity

Activity

Activity Endpoint LD50

Activity Raw

LD50 =>1000 µg/ml

Detail Source Activity Anticancer

Activity Measurement >1000 µg/mL

Target

Cancer Type Skin Cancer

Cell Line BMKC

Tissue Affected Skin

Assay & Model

Assay MTT/MTS assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0 SATPdb

Source CancerPPD2

Year 2005

Patents US_06875744_B2

Evidence 4 Activity

Activity

Activity Endpoint LD50

Activity Raw

LD50 =>1000 µg/ml

Detail Source Activity Anticancer

Activity Measurement >1000 µg/mL

Target

Cancer Type Lung Cancer

Cell Line H-1299

Tissue Affected Lung

Assay & Model

Assay MTT/MTS assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0 SATPdb

Source CancerPPD2

Year 2005

Patents US_06875744_B2

Evidence 5 Activity

Activity

Activity Endpoint LD50

Activity Raw

LD50 =>1000 µg/ml

Detail Source Activity Anticancer

Activity Measurement >1000 µg/mL

Target

Cancer Type Prostate Cancer

Cell Line PC-3

Tissue Affected Prostate

Assay & Model

Assay MTT/MTS assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0 SATPdb

Source CancerPPD2

Year 2005

Patents US_06875744_B2

Evidence 6 Activity

Activity

Activity Endpoint LD50

Activity Raw

LD50 = >1000 µg/ml

Detail Source Activity Anticancer

Activity Measurement >1000 µg/mL

Target

Cancer Type Cervical Cancer

Cell Line HeLa

Tissue Affected Cervix

Assay & Model

Assay MTT/MTS assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0 SATPdb

Source CancerPPD2

Year 2005

Patents US_06875744_B2