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Peptide record

TPDB40980

ACE inhibitor ACE inhibitors Anticancer Antihypertensive standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB40980
ACE inhibitor
ACE inhibitors Anticancer Antihypertensive
Cardiometabolic peptides Cancer-related peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 10-aa standard natural multi-activity (ACE inhibitors, Anticancer, and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
ENLHLPLPLL
Physicochemical Analysis
C55H91N13O14
ARDCQGIKMFSTWYV
L
1158.41
5.13
1
1
5
-1
1.50
0.560
195.00
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
0
R
1
N
0
D
0
C
1
E
0
Q
0
G
1
H
0
I
5
L
0
K
0
M
0
F
2
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 1 I: 0 L: 5 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
10
C55H91N13O14
1158.41
5.13
-1
1.50
0.560
1158.3861
1157.6787
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
250.00 µM
Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Robert M. C., Razaname A., Mutter M., Juillerat M. A.
Identification of angiotensin-I-converting enzyme inhibitory peptides derived from sodium caseinate hydrolysates produced by Lactobacillus helveticus NCC 2765. J. Agric. Food. Chem., 52, 6923-6931, 2004
2004
Journal

Other

10
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@H](CC1=CN=C[NH]1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)O InChI=1S/C55H91N13O14/c1-28(2)19-35(61-50(76)38(25-44(57)69)60-46(72)34(56)15-16-45(70)71)47(73)62-37(24-33-26-58-27-59-33)49(75)64-39(21-30(5)6)53(79)68-18-12-14-43(68)52(78)65-40(22-31(7)8)54(80)67-17-11-13-42(67)51(77)63-36(20-29(3)4)48(74)66-41(55(81)82)23-32(9)10/h26-32,34-43H,11-25,56H2,1-10H3,(H2,57,69)(H,58,59)(H,60,72)(H,61,76)(H,62,73)(H,63,77)(H,64,75)(H,65,78)(H,66,74)(H,70,71)(H,81,82)/t34-,35-,36-,37-,38-,39-,40-,41-,42-,43-/m0/s1 InChIKey=DTXZRWJTBCMKMM-IJXJCFDCSA-N Anticancer peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8316), the DFBP database
Evidence 2 Activity

Activity

IC50
Antihypertensive
250.00 µM
Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Robert M. C., Razaname A., Mutter M., Juillerat M. A.
Identification of angiotensin-I-converting enzyme inhibitory peptides derived from sodium caseinate hydrolysates produced by Lactobacillus helveticus NCC 2765. J. Agric. Food. Chem., 52, 6923-6931, 2004
2004
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
10
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@H](CC1=CN=C[NH]1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)O InChI=1S/C55H91N13O14/c1-28(2)19-35(61-50(76)38(25-44(57)69)60-46(72)34(56)15-16-45(70)71)47(73)62-37(24-33-26-58-27-59-33)49(75)64-39(21-30(5)6)53(79)68-18-12-14-43(68)52(78)65-40(22-31(7)8)54(80)67-17-11-13-42(67)51(77)63-36(20-29(3)4)48(74)66-41(55(81)82)23-32(9)10/h26-32,34-43H,11-25,56H2,1-10H3,(H2,57,69)(H,58,59)(H,60,72)(H,61,76)(H,62,73)(H,63,77)(H,64,75)(H,65,78)(H,66,74)(H,70,71)(H,81,82)/t34-,35-,36-,37-,38-,39-,40-,41-,42-,43-/m0/s1 InChIKey=DTXZRWJTBCMKMM-IJXJCFDCSA-N Anticancer peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8316), the DFBP database
Additional Detail Fields 1 fields
10