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Peptide record

TPDB40947

GV1001 Anti-inflammatory Anticancer Cell-penetrating Peptides standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB40947
GV1001
Anti-inflammatory Anticancer Cell-penetrating Peptides
Cancer-related peptides Immunity and inflammation peptides Delivery and barrier-penetrating peptides
AIPpred Peptipedia CancerPPD 2.0 CPPsite3.0 MLCPP 2.0 PerseuCPP
standard
No
A 16-aa standard natural multi-activity (Anti-inflammatory, Anticancer, and Cell-penetrating Peptides) peptide sequence curated from AIPpred, Peptipedia, CancerPPD 2.0, and other sources, with an available 3D structural model.
Sequence
EARPALLTSRLRFIPK
Physicochemical Analysis
C85H146N26O21
NDCQGHMWYV
RL
1868.26
12.12
4
1
7
+3
3.15
-0.206
110.00
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
0
0.00
2
Residue Composition
number
2
A
3
R
0
N
0
D
0
C
1
E
0
Q
0
G
0
H
1
I
3
L
1
K
0
M
1
F
2
P
1
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 3 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 1 L: 3 K: 1 M: 0 F: 1 P: 2 S: 1 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
16
C85H146N26O21
1868.26
12.12
+3
3.15
-0.206
Free
L
Linear
Linear
Free
Anticancer
Human telomerase reverse transcriptase (hTERT)
N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Graph Fig 2A
Anticancer

Target

Lung Cancer
A-549
Lung

Assay & Model

Cell Viability assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2022

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

Huh7, MCF7, Jurkat, Raji, THP1, and K562 cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
Protein (eGFP)
Clathrin- mediated Endocytosis and heparan sulfate proteoglycan
In vitro
CCSTTCTHHHHTCCCC
Additional Detail Fields 1 fields
CCSTTCTHHHHTCCCC