TPDB

3D PDB MODEL

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TPDB ID TPDB40927

Peptide_Name

PC4-5 PC5- 4

Activity

Anticancer Tumor-homing Peptides

Activity_category_statistics

Cancer-related peptides

Database_Source

Peptipedia StackTHP StackTHPred TumorHoPe2.0

Sequence_Type

standard

Has_Modification No

Description A 12-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.

Sequence

DMPKQLLAPWYY

FASTA

>TPDB40927|Anticancer;Tumor-homing Peptides|length=12
DMPKQLLAPWYY

Formula C74H105N15O18S1

Absent Amino Acids RNCEGHIFSTV

Common Amino Acids LPY

Mass 1524.80

PI 6.63

Basic Residues 1

Acidic Residues 1

Hydrophobic Residues 7

Net Charge -0

Boman Index -1.55

Hydrophobicity -0.525

Aliphatic Index 73.33

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour

Extinction Coefficient Cystines 8480

Absorbance 280nm 556.14

Polar Residues 3

number

1

A

0

R

0

N

1

D

0

C

0

E

1

Q

0

G

0

H

0

I

2

L

1

K

1

M

0

F

2

P

0

S

0

T

1

W

2

Y

0

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 2 K: 1 M: 1 F: 0 P: 2 S: 0 T: 0 W: 1 Y: 2 V: 0

Length

12

Formula

C74H105N15O18S1

Mass

1524.80

PI

6.63

Net Charge

-0

Boman Index

-1.55

Hydrophobicity

-0.525

Motif

WTYY

Evidence 1 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Homing or Targeting Targeting

Target Tumor Lung cancer, non-small cell lung cancer (NSCLC)

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title A Novel Peptide Enhances Therapeutic Efficacy of Liposomal Anti-Cancer Drugs in Mice Models of Human Lung Cancer

Year 2009

Reference

Chang DK et al. PLoS One. 2009 4(1):e4171.

Patent US 2008/0193375A1

Other

Source Activity Label	Source Definition
Tumor-homing Peptides	TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.

InVitro ExVivo CL1-5, PC13, Specimens of pulmonary adenocarcinoma

Source Type Phage display library

Phage Display Library M15 phage /random peptide library

Evidence 2 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Homing or Targeting Targeting

Target Tumor Lung cancer, non-small cell lung cancer (NSCLC)

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title A Novel Peptide Enhances Therapeutic Efficacy of Liposomal Anti-Cancer Drugs in Mice Models of Human Lung Cancer

Year 2009

Reference

Chang DK et al. PLoS One. 2009 4(1):e4171.

Patent US 2008/0193375A1

Other

InVitro ExVivo CL1-5, PC13, Specimens of pulmonary adenocarcinoma

Source Type Phage display library

Phage Display Library M15 phage /random peptide library

InVitro_ExVivo

CL1-5, PC13, Specimens of pulmonary adenocarcinoma

Phage_Display_Library

M15 phage /random peptide library