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Peptide record

TPDB40874

Anticancer Tumor-homing Peptides standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB40874
Anticancer Tumor-homing Peptides
Cancer-related peptides
Peptipedia StackTHP StackTHPred TumorHoPe2.0
standard
No
A 9-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.
Sequence
CVLNGRMEC
Physicochemical Analysis
C39H69N13O13S3
ADQHIKFPSTWY
C
1024.24
6.14
1
1
3
-0
2.06
0.333
75.56
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
125
12.20
3
Residue Composition
number
0
A
1
R
1
N
0
D
2
C
1
E
0
Q
1
G
0
H
0
I
1
L
0
K
1
M
0
F
0
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 1 D: 0 C: 2 E: 1 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 0 M: 1 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
9
C39H69N13O13S3
1024.24
6.14
-0
2.06
0.333
NGR
Evidence Records 3 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Homing
Breast cancer

Source & Reference

TumorHoPe2.0
TumorHoPe2
Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis
2000
Pasqualini R et al. Cancer Res. 2000 Feb 1 60(3):722-7.
US 2009/0257951 A1

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
MDA-MB-435 breast cancer cells transfected with APN cDNA.
Mice bearing MDA-MB-435 tumors
Phage display library
M13 phage /CX3CX3CX3C peptide library
Doxorubicin
Evidence 2 Activity

Activity

Tumor-homing Peptides

Target

Endothelial cell
Homing
Mouse melanoma
Integrin

Source & Reference

TumorHoPe2.0
TumorHoPe2
Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model
1999
Arap W et al. Science. 1998 Jan 16 279(5349):377-80.
US2009/0257951 A1

Other

Mice bearing MDA-MB-435derived tumors, SLK cell derived human Kaposi's sarcoma xenografts
Phage display library
M13 Phage/CX3CX3CX3C peptide library
Evidence 3 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, Tumor vessel, Tumor stem cell, Endothelial cell, Epithelial cell, Dendritic cell
Homing

Source & Reference

TumorHoPe2.0
TumorHoPe2
Methods and compositions using peptides and proteins with C-terminal elements
2019
US 10370245 B2
US 10370245 B2

Other

PPC-1, PC-3, Du-145, 4T1, MIA PaCa-2, PDAC1.3, B16F10, M21, and MDA-MB-435 cell line
BALB/c athymic nude mice
Phage Display library
T7 phage display library
nanoparticles, nanoworms, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)2000 DSPE-PEG2000-maleimide]
Additional Detail Fields 4 fields
Doxorubicin nanoparticles, nanoworms, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)2000 DSPE-PEG2000-maleimide]
MDA-MB-435 breast cancer cells transfected with APN cDNA. PPC-1, PC-3, Du-145, 4T1, MIA PaCa-2, PDAC1.3, B16F10, M21, and MDA-MB-435 cell line
Mice bearing MDA-MB-435 tumors Mice bearing MDA-MB-435derived tumors, SLK cell derived human Kaposi's sarcoma xenografts BALB/c athymic nude mice
M13 phage /CX3CX3CX3C peptide library M13 Phage/CX3CX3CX3C peptide library T7 phage display library