TPDB

3D PDB MODEL

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TPDB ID TPDB40856

Activity

Anticancer Tumor-homing Peptides

Activity_category_statistics

Cancer-related peptides

Database_Source

Peptipedia StackTHP StackTHPred TumorHoPe2.0

Sequence_Type

standard

Has_Modification No

Description A 9-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.

Sequence

CSRPRRSEC

FASTA

>TPDB40856|Anticancer;Tumor-homing Peptides|length=9
CSRPRRSEC

Formula C40H72N18O14S2

Absent Amino Acids ANDQGHILKMFTWYV

Common Amino Acids R

Mass 1093.24

PI 9.19

Basic Residues 3

Acidic Residues 1

Hydrophobic Residues 0

Net Charge +2

Boman Index 4.68

Hydrophobicity -1.689

Aliphatic Index 0.00

Half Life

Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 125

Absorbance 280nm 11.43

Polar Residues 4

number

0

A

3

R

0

N

0

D

2

C

1

E

0

Q

0

G

0

H

0

I

0

L

0

K

0

M

0

F

1

P

2

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 3 N: 0 D: 0 C: 2 E: 1 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 2 T: 0 W: 0 Y: 0 V: 0

Length

9

Formula

C40H72N18O14S2

Mass

1093.24

PI

9.19

Net Charge

+2

Boman Index

4.68

Hydrophobicity

-1.689

Motif

CendR

Evidence 1 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Vasculature of earlier stage dysplasias

Homing or Targeting Homing

Target Tumor Epidermal squamous cell cancers

Receptors Biomarker MECA32 (Second endothelial marker, the cell-surface antigen)

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title Progressive vascular changes in a transgenic mouse model of squamous cell carcinoma

Year 2003

Reference

Hoffman JA et al. Cancer Cell. 2003 Nov 4(5):383-91.

Patent WO0503949542,US20050245445A1

Other

Source Activity Label	Source Definition
Tumor-homing Peptides	TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.

InVivo Model K14-HPV16 mice, FVB/b mice , C57B16 cells bearing mice,RIP1-Tag2 mice

Source Type Phage display library

Phage Display Library T7 phage /9-mer cyclic (CX7C) peptide library

Evidence 2 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Tumor cell

Homing or Targeting Targeting

Target Tumor Melanoma

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title Compositions of a peptide targeting system for treating cancer

Year 2014

Reference

US 8680045 B2

Patent US 8680045 B2

Other

InVitro ExVivo WM-266-4

InVivo Model Nude mice (20 g)

Source Type Phage display library

Conjugate Payload Cy5.5

Evidence 3 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Tumor cell, Tumor vessel, Tumor stem cell, Endothelial cell,

Homing or Targeting Homing

Receptors Biomarker gC1q/p32 receptor

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title Targeted delivery system and methods of use therefor

Year 2022

Reference

US 11512110 B2

Patent US 11512110 B2

Other

InVivo Model Athymic nude mice, ApoE null mice

Source Type Phage display library

Phage Display Library T7 phage / cyclic Cx7C and linear X7 peptide library

Conjugate Payload Nanoworms(NWs), polyethylene glycol

Evidence 4 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Tumor cell, Tumor vessel, Tumor stem cell, Endothelial cell,

Homing or Targeting Homing

Receptors Biomarker gC1q/p32 receptor

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title Targeted delivery system and methods of use therefor

Year 2022

Reference

US 11512110 B2

Patent US 11512110 B2

Other

InVivo Model Athymic nude mice, ApoE null mice

Source Type Phage display library

Phage Display Library T7 phage / cyclic Cx7C and linear X7 peptide library

Conjugate Payload Nanoworms(NWs), polyethylene glycol

Evidence 5 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Tumor cell, Tumor vessel, Tumor stem cell, Endothelial cell, Epithelial cell, Dendritic cell

Homing or Targeting Homing

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title Methods and compositions using peptides and proteins with C-terminal elements

Year 2019

Reference

US 10370245 B2

Patent US 10370245 B2

Other

InVitro ExVivo PPC-1, PC-3, Du-145, 4T1, MIA PaCa-2, PDAC1.3, B16F10, M21, and MDA-MB-435 cell line

InVivo Model BALB/c athymic nude mice

Source Type Phage Display library

Phage Display Library T7 phage display library

Conjugate Payload nanoparticles, nanoworms, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)2000 DSPE-PEG2000-maleimide]

Conjugate_Payload

Cy5.5 Nanoworms(NWs), polyethylene glycol nanoparticles, nanoworms, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)2000 DSPE-PEG2000-maleimide]

InVitro_ExVivo

WM-266-4 PPC-1, PC-3, Du-145, 4T1, MIA PaCa-2, PDAC1.3, B16F10, M21, and MDA-MB-435 cell line

InVivo_Model

K14-HPV16 mice, FVB/b mice , C57B16 cells bearing mice,RIP1-Tag2 mice Nude mice (20 g) Athymic nude mice, ApoE null mice BALB/c athymic nude mice

Phage_Display_Library

T7 phage /9-mer cyclic (CX7C) peptide library T7 phage / cyclic Cx7C and linear X7 peptide library T7 phage display library