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Peptide record

TPDB40830

RGR RGR peptide Anticancer Tumor-homing Peptides standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB40830
RGR RGR peptide
Anticancer Tumor-homing Peptides
Cancer-related peptides
Peptipedia StackTHP StackTHPred TumorHoPe2.0
standard
No
A 7-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.
Sequence
CRGRRST
Physicochemical Analysis
C30H58N16O10S1
ANDEQHILKMFPWYV
R
834.95
12.10
3
0
0
+3
2.47
-1.843
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
3
Residue Composition
number
0
A
3
R
0
N
0
D
1
C
0
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
1
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 1 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
7
C30H58N16O10S1
834.95
12.10
+3
2.47
-1.843
RGRRS, RGRR CendR
Evidence Records 5 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Endothelial cellor pericytes
Homing
Pancreatic islet carcinoma

Source & Reference

TumorHoPe2.0
TumorHoPe2
Stage-specific vascular markers revealed by phage display in a mouse model of pancreatic islet tumorigenesis
2003
Joyce JA et al. Cancer Cell. 2003 Nov 4(5):393-403.
WO05041882A2,US20050245445A1

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
Prototypical mouse model of multistage tumorigenesis, RIP1-Tag2 transgenic model of islet cell carcinoma and K14-HPV16 mice
Phage display library
T7 phage/CX7C peptide library
neoplastic vascular specialization might exist in tumor development
Evidence 2 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, Tumor vessel, Tumor stem cell, Endothelial cell,
Homing
gC1q/p32 receptor

Source & Reference

TumorHoPe2.0
TumorHoPe2
Targeted delivery system and methods of use therefor
2022
US 11512110 B2
US 11512110 B2

Other

Athymic nude mice, ApoE null mice
Phage display library
T7 phage / cyclic Cx7C and linear X7 peptide library
Nanoworms(NWs), polyethylene glycol
Evidence 3 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, Tumor vessel, Tumor stem cell, Endothelial cell,
Homing
gC1q/p32 receptor

Source & Reference

TumorHoPe2.0
TumorHoPe2
Targeted delivery system and methods of use therefor
2022
US 11512110 B2
US 11512110 B2

Other

Athymic nude mice, ApoE null mice
Phage display library
T7 phage / cyclic Cx7C and linear X7 peptide library
Nanoworms(NWs), polyethylene glycol
Evidence 4 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Lung cancer, Breast cancer, Liver cancer, Melanoma, stomach cancer, Pancreatic cancer, Colorectal cancer, Ovarian cancer, Renal cell carcinoma, Prostate cancer, Brain tumor

Source & Reference

TumorHoPe2.0
TumorHoPe2
Noxa-derived, cell death-inducing peptide eMTD
2022
US 11248024 B2
US 11248024 B2

Other

Sp2/0, CHO (Chinese hamster ovary) K1, CHO DG44, PER.C6, W138, BHK, COS7, 293, HepG2, Huh7, 3T3, RIN, MDCK cell line
6-week-old BalB/C mice
Synthetic
necrosis-inducing peptide, Fluorescein (FAM)
Evidence 5 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, Endothelial cell, Tumor vessel
Homing
Colorectal cancer
VEGFR, EGFR

Source & Reference

TumorHoPe2.0
TumorHoPe2
A novel tumor-homing TRAIL variant eradicates tumor xenografts of refractory colorectal cancer cells in combination with tumor cell-targeted photodynamic therapy
2022
Zhao Li et al. Drug Deliv. 2022 Dec 29(1):1698-1711.

Other

Human cancer cells (COLO205, LS174T, HCT116, HT29, HCT8, MDA-MB-231, MCF-7, A549, NIC-H460, HuCCT1, DU145, HT1080, U251, A375) and human umbilical vein endothelial cells (HUVECs), Human colorectal cancer cells (LIM1215)
Balb/c nude mice
Synthetic
tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)
Additional Detail Fields 4 fields
Nanoworms(NWs), polyethylene glycol necrosis-inducing peptide, Fluorescein (FAM) tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)
Sp2/0, CHO (Chinese hamster ovary) K1, CHO DG44, PER.C6, W138, BHK, COS7, 293, HepG2, Huh7, 3T3, RIN, MDCK cell line Human cancer cells (COLO205, LS174T, HCT116, HT29, HCT8, MDA-MB-231, MCF-7, A549, NIC-H460, HuCCT1, DU145, HT1080, U251, A375) and human umbilical vein endothelial cells (HUVECs), Human colorectal cancer cells (LIM1215)
Prototypical mouse model of multistage tumorigenesis, RIP1-Tag2 transgenic model of islet cell carcinoma and K14-HPV16 mice Athymic nude mice, ApoE null mice 6-week-old BalB/C mice Balb/c nude mice
T7 phage/CX7C peptide library T7 phage / cyclic Cx7C and linear X7 peptide library