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Peptide record

TPDB40828

cRGD iRGD Anticancer Blood-Brain Barrier Cell-penetrating Peptides Tumor-homing Peptides standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB40828
cRGD iRGD
Anticancer Blood-Brain Barrier Cell-penetrating Peptides Tumor-homing Peptides
Cancer-related peptides Delivery and barrier-penetrating peptides
Peptipedia BBPpredict CPPsite3.0 StackTHP StackTHPred TumorHoPe2.0
standard
No
A 9-aa standard natural multi-activity (Anticancer, Blood-Brain Barrier, Cell-penetrating Peptides, and other sources) peptide sequence curated from Peptipedia, BBPpredict, CPPsite3.0, and other sources, with an available 3D structural model.
Sequence
CRGDRGPDC
Physicochemical Analysis
C35H59N15O14S2
ANEQHILKMFSTWYV
RDCG
978.07
6.09
2
2
0
-0
4.07
-1.489
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
125
12.78
2
Residue Composition
number
0
A
2
R
0
N
2
D
2
C
0
E
0
Q
2
G
0
H
0
I
0
L
0
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 2 C: 2 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
9
C35H59N15O14S2
978.07
6.09
-0
4.07
-1.489
Free
L
Cyclic
RGD
Free
NCC(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)O
Evidence Records 4 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MDA-MB-231, Calu-3, 4T1 And 4T1 Cells

Assay & Model

MDA-MB-231 breast tumor xenograft mouse model of BALB/c nude mice (female, 4–5 weeks, 18–22 g)
MDA-MB-231 breast tumor xenograft mouse model of BALB/c nude mice (female, 4–5 weeks, 18–22 g)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Cyclic L
Gambogic acid(GA), nanostructured lipid carrier(NLC) , coumarin-6
Intracellular quantitative fluorescence intensity of coumarin-6-NLC-cRGD is 254.4 ± 93.19
Endocytosis
In-vitro, in-vivo and ex vivo
CCCCCCSSCCSCCSCHHHHHHTGGGCC
Evidence 2 Activity

Activity

Tumor-homing Peptides

Target

Endothelial cell and tumor cell
Targeting
Prostate cancer
Alpha 5 beta 3 and Alpha 5 beta 5 integrins neuropilin-1

Source & Reference

TumorHoPe2.0
TumorHoPe2
Tissue-penetrating delivery of compounds and nanoparticles into tumors
2009
Sugahara KN et al. Cancer Cell. 2009 Dec 8 16(6):510-20.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
Cultured PPC1 human prostate cancer cells, M21 human melanoma cells
Phage display library
T7 phage / CX7C peptide library
Evidence 3 Activity

Activity

Tumor-homing Peptides

Target

Endothelial cell, Tumor cell, Tumor vessel
Homing
Prostate cancer
neuropilin-1

Source & Reference

TumorHoPe2.0
TumorHoPe2
Amphipathic tail-anchoring peptide is a promising therapeutic agent for prostate cancer treatment
2014
Gejing De et al. Oncotarget. 2014 Sep 15 5(17):7734-47.

Other

prostate cancer cells (DU145, LNCaP and PC-3), U87 glioblastoma cells, MDA-MB-231 breast adenocarcinoma cells, and KYSE-150 esophageal squamous carcinoma cells
Five week-old NCR nude mice
Amphipathic tail-anchoring peptide (ATAP)
Evidence 4 Activity

Activity

Tumor-homing Peptides

Target

Endothelial cell, Tumor cell, Tumor vessel
Homing
NRP-1

Source & Reference

TumorHoPe2.0
TumorHoPe2
A tumor-penetrating peptide enhances circulation-independent targeting of peritoneal carcinomatosis
2015
Kazuki N Sugahara et al. J Control Release. 2015 Aug 28:212:59-69.

Other

Lovo-6-luc-1 human colon cancer cells, MKN45P human gastric cancer cells
nude mice
Synthetic
FAM
cyclic
Additional Detail Fields 5 fields
Amphipathic tail-anchoring peptide (ATAP) FAM
CCCCCCSSCCSCCSCHHHHHHTGGGCC
Cultured PPC1 human prostate cancer cells, M21 human melanoma cells prostate cancer cells (DU145, LNCaP and PC-3), U87 glioblastoma cells, MDA-MB-231 breast adenocarcinoma cells, and KYSE-150 esophageal squamous carcinoma cells Lovo-6-luc-1 human colon cancer cells, MKN45P human gastric cancer cells
Five week-old NCR nude mice nude mice
T7 phage / CX7C peptide library