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Peptide record

TPDB40823

iRGD iRGD-CDD PC-CC9/miRNA Anticancer Blood-Brain Barrier Cell-penetrating Peptides Tumor-homing Peptides standard
9 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB40823
iRGD iRGD-CDD PC-CC9/miRNA
Anticancer Blood-Brain Barrier Cell-penetrating Peptides Tumor-homing Peptides
Cancer-related peptides Delivery and barrier-penetrating peptides
Peptipedia BBPpredict CPPsite3.0 MLCPP 2.0 StackTHP StackTHPred TumorHoPe2.0
standard
No
A 9-aa standard natural multi-activity (Anticancer, Blood-Brain Barrier, Cell-penetrating Peptides, and other sources) peptide sequence curated from Peptipedia, BBPpredict, CPPsite3.0, and other sources, with an available 3D structural model.
Sequence
CRGDKGPDC
Physicochemical Analysis
C35H59N13O14S2
ANEQHILMFSTWYV
DCG
950.05
6.09
2
2
0
-0
4.25
-1.422
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
125
13.16
2
Residue Composition
number
0
A
1
R
0
N
2
D
2
C
0
E
0
Q
2
G
0
H
0
I
0
L
1
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 2 C: 2 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
9
C35H59N13O14S2
950.05
6.09
-0
4.25
-1.422
Free
L
Cationic
Linear Cyclic
RGD cendR RGD, CendR (R/KXXR/K) CendR (CRGDK) CendR (R/KXXR/K) CendR motif (R/KXXR/K)
Free
N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CS)C(=O)O N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
Evidence Records 36 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Human embryonic kidney (HEK) 293T, prostate cancer PPC1,mouse breast cancer 4T1, Human tumor cell line M21, Human breast cancer cell line MCF-10CA1a

Assay & Model

Athymic nude mice and Balb/C mice
Athymic nude mice and Balb/C mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Fluorophore (Red fluorophor Dy550)
Cytoplasm
In vitro and in vivo
CCSSCSSCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

PANC-1 and 293T cells

Assay & Model

Mice
Mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Cyclic L Cationic
Synthetic
Nucleic acid (miRNA)
PC-CC9/FAM-siRNA and PC/ FAM-siRNA CC9 could approach PANC-1 cells quickly
In vitro and in vivo
CCSSCSSCC
Evidence 3 Activity

Activity

Cell-penetrating Peptides

Target

B16F10 And 4T1 Cells

Assay & Model

Female wild-type BALB/c mice (age: 4–6 weeks, weight: 20 ± 2 g) and female C57BL/6 mice (age: 4–6 weeks, weight: 20 ± 2 g)
Female wild-type BALB/c mice (age: 4–6 weeks, weight: 20 ± 2 g) and female C57BL/6 mice (age: 4–6 weeks, weight: 20 ± 2 g)

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
ST-4
Fluorescence of ST-4-iRGD located on B16F10 (treated by negative control siRNA [NC]) was enhanced when compared with that by ST-4 alone.
In vitro and in vivo
CCCCCSBSSSBSCCSSSCC
Evidence 4 Activity

Activity

Cell-penetrating Peptides

Target

HEK293T cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Non-natural residues Linear L
Synthetic
Cre protein
Cytoplasm
Did not promote protein delivery relative to the Cre-only
In vitro
Evidence 5 Activity

Activity

Tumor-homing Peptides

Target

Endothelial cell and tumor cell
Homing
Prostate, Pancreatic ductal, breast cancer, bone , brain, cervical cancer
Alpha 5 beta 3 and Alpha 5 beta 5 integrins neuropilin-1

Source & Reference

TumorHoPe2.0
TumorHoPe2
Tissue-penetrating delivery of compounds and nanoparticles into tumors
2009
Sugahara KN et al. Cancer Cell. 2009 Dec 8 16(6):510-20.
US 2009/0246133A1

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
Cultured PPC1 human prostate cancer cells, M21 human melanoma cells
Nude mice with multiple tumors (prostrate PC-3, PPC1, 22RVI Xenograft), (pancreatic MIAPaCa-2 Xenograft)
Phage display library
T7 phage / CX7C peptide library
Iron oxide nanoworms, iRGD-linked abraxane
Evidence 6 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Targeting
Breast cancer, Ovarian cancer
neuropilin-1

Source & Reference

TumorHoPe2.0
TumorHoPe2
Compositions for treating cancer and methods for making the same
2019
US 10300143 B2
US 10300143 B2

Other

4T1 breast cancer cell line, MDA-MB-468 breast cancer cell line, 4306-ovarian cancer cell line, Lewis lung carcinoma (LLC) cells, hepatocellular carcinoma cells (CP20)
BALB/c mice
Synthetic
diacylglycerols, dialkylglycerols
Evidence 7 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, Tumor vessel, Tumor stem cell, Endothelial cell,
Homing
gC1q/p32 receptor

Source & Reference

TumorHoPe2.0
TumorHoPe2
Targeted delivery system and methods of use therefor
2022
US 11512110 B2
US 11512110 B2

Other

Athymic nude mice, ApoE null mice
Phage display library
T7 phage / cyclic Cx7C and linear X7 peptide library
Nanoworms(NWs), polyethylene glycol
Evidence 8 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Lung cancer, Breast cancer, Liver cancer, Melanoma, stomach cancer, Pancreatic cancer, Colorectal cancer, Ovarian cancer, Renal cell carcinoma, Prostate cancer, Brain tumor

Source & Reference

TumorHoPe2.0
TumorHoPe2
Noxa-derived, cell death-inducing peptide eMTD
2022
US 11248024 B2
US 11248024 B2

Other

Sp2/0, CHO (Chinese hamster ovary) K1, CHO DG44, PER.C6, W138, BHK, COS7, 293, HepG2, Huh7, 3T3, RIN, MDCK cell line
6-week-old BalB/C mice
Synthetic
necrosis-inducing peptide, Fluorescein (FAM)
Evidence 9 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, Tumor vessel, Tumor stem cell, Endothelial cell, Epithelial cell, Dendritic cell
Homing
Lung cancer, Breast cancer, Liver cancer, Melanoma, Pancreatic cancer, Colorectal cancer, Prostate cancer
neuropilin-1 (NRP1)

Source & Reference

TumorHoPe2.0
TumorHoPe2
Methods and compositions using peptides and proteins with C-terminal elements
2019
US 10370245 B2
US 10370245 B2

Other

PPC-1, PC-3, Du-145, 4T1, MIA PaCa-2, PDAC1.3, B16F10, M21, and MDA-MB-435 cell line
BALB/c athymic nude mice
Phage Display library
T7 phage display library
nanoparticles, nanoworms, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)2000 DSPE-PEG2000-maleimide]
cell penetrating
Evidence 10 Activity

Activity

Tumor-homing Peptides

Target

Tumor vessel
Homing
Melanoma, Lung cancer
αv integrins, neuropilin-1

Source & Reference

TumorHoPe2.0
TumorHoPe2
Immunomodulatory and enhanced antitumor activity of a modified thymosin α1 in melanoma and lung cancer
2018
Fanwen Wang et al. Int J Pharm. 2018 Aug 25 547(1-2):611-620.

Other

B16F10 and H460 cells
Female BALB/c nude mice (5–6weeks old), C57BL/6 mice, ICR mice (7–8weeks old)
Synthetic
hormone thymosin α1 (Tα1)
Evidence 11 Activity

Activity

Tumor-homing Peptides

Target

Homing

Source & Reference

TumorHoPe2.0
TumorHoPe2
2022
Zhaoli Sun et al. ACS Nano. 2022 Aug 23 16(8):11862-11875.

Other

MnO@mSiO2 nanoparticles
Evidence 12 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Colon cancer
Integrin αVβ3, αVβ5, Neuropilin-1 (NRP-1)

Source & Reference

TumorHoPe2.0
TumorHoPe2
Anticancer activity of Helicobacter pylori ribosomal protein (HPRP) with iRGD in treatment of colon cancer
2021
Atieh Yaghoubi et al. J Cancer Res Clin Oncol. 2021 Oct 147(10):2851-2865.

Other

CT26 murine colorectal carcinoma cells, HT29 human colon cancer cells, L929 fibroblast cells
Seven-week-old female inbred Balb/C mice
Synthetic
5-Fluorouracil, HPRP-A1
Evidence 13 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Pancreatic cancer
Integrin αVβ3, αVβ5, Neuropilin-1 (NRP-1)

Source & Reference

TumorHoPe2.0
TumorHoPe2
The effect of superparamagnetic iron oxide with iRGD peptide on the labeling of pancreatic cancer cells in vitro: a preliminary study
2014
Hou Dong Zuo et al. Biomed Res Int. 2014:2014:852352.

Other

Panc-1 human pancreatic cancer cells
Nude mice
Synthetic
Superparamagnetic iron oxide nanoparticles (SPIO)
Evidence 14 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Gastric cancer
Neuropilin-1 (NRP1)

Source & Reference

TumorHoPe2.0
TumorHoPe2
Combination of NRP1-mediated iRGD with 5-fluorouracil suppresses proliferation, migration and invasion of gastric cancer cells
2017
Li Zhang et al. Biomed Pharmacother. 2017 Sep:93:1136-1143.

Other

NCI-N87, SGC-7901, AGS, HGC27 gastric cancer cells, human immortalized gastric epithelial cell line(GES-1)
male BALB/c nude mice(4-week-old)
Synthetic
5-Fluorouracil (5-FU)
Evidence 15 Activity

Activity

Tumor-homing Peptides

Target

Tumor vessel
Homing
Orthotopic Breast cancer
αvβ3 integrin, Neuropilin-1 (NRP1)

Source & Reference

TumorHoPe2.0
TumorHoPe2
An Oxygen Self-sufficient Fluorinated Nanoplatform for Relieved Tumor Hypoxia and Enhanced Photodynamic Therapy of Cancers
2019
Shengnan Ma et al. ACS Appl Mater Interfaces. 2019 Feb 27 11(8):7731-7742.

Other

4T1 murine breast cancer cells
BALB/c female mice (4−6 week old)
Synthetic
IR780, Oxygen-loaded pH-sensitive fluorocarbon-functionalized nanoparticles (SFNs)
Evidence 16 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, Tumor vessel, Endothelial cell
Homing
B16-F10 Melanoma
αv integrin receptor, Neuropilin-1 (NRP-1)

Source & Reference

TumorHoPe2.0
TumorHoPe2
The antitumor activity of a doxorubicin loaded, iRGD-modified sterically-stabilized liposome on B16-F10 melanoma cells: in vitro and in vivo evaluation
2013
Ke-Fu Yu et al. Int J Nanomedicine. 2013:8:2473-85.

Other

B16-F10 murine melanoma cells
Female BALB (Bagg Albino)/c nude mice weighing 20–25 g (5–6 weeks old), female C57BL/6 mice weighing 20–24 g (5–6 weeks old)
Synthetic
Doxorubicin (DOX), sterically-stabilized liposome (SSL)
Evidence 17 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Breast cancer
Neuropilin-1 (NRP-1)

Source & Reference

TumorHoPe2.0
TumorHoPe2
Caged Pt nanoclusters exhibiting corrodibility to exert tumor-inside activation for anticancer chemotherapeutics
2013
Chih-Te Chien et al. Adv Mater. 2013 Sep 25 25(36):5067-73.

Other

MDA-MB-231 breast cancer cells
nude mice
Platinum nanoclusters (PN), PEG, G2 NH2 (amine-terminated dendrimer)
Evidence 18 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Solid tumors (Glioma, Breast cancer)
αv integrins, neuropilin-1

Source & Reference

TumorHoPe2.0
TumorHoPe2
Nanoparticles That Reshape the Tumor Milieu Create a Therapeutic Window for Effective T-cell Therapy in Solid Malignancies
2018
Fan Zhang et al. Cancer Res. 2018 Jul 1. 78(13):3718-3730.

Other

4T1 breast cancer cells, PDGF-driven glioma cells
Female BALB/cJ mice (4–6 weeks old)
Synthetic
Lipid nanoparticles, PI-3065, 7DW8-5
Evidence 19 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Breast cancer
αvβ3 integrin

Source & Reference

TumorHoPe2.0
TumorHoPe2
Coadministration of iRGD with Multistage Responsive Nanoparticles Enhanced Tumor Targeting and Penetration Abilities for Breast Cancer Therapy
2018
Chuan Hu et al. ACS Appl Mater Interfaces. 2018 Jul 5. 10(26) 22571-22579

Other

Mouse mammary breast tumor cell line (4T1), A2780 cell line
Female BALB/C mice (6 weeks old)
Synthetic
multistageresponsive nanoparticle (IDDHN) (Dendri Graft L Lysine, doxorubicin, indocyanine)
Evidence 20 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, Tumor vessel, Endothelial cell
Homing
Breast cancer, Liver carcinoma
αvβ3 integrin

Source & Reference

TumorHoPe2.0
TumorHoPe2
Hyperthermia-triggered drug delivery from iRGD-modified temperature-sensitive liposomes enhances the anti-tumor efficacy using high intensity focused ultrasound
2016
Zhiting Deng et al. J Control Release. 2016 Dec 10. 243(333-341)

Other

4T1 mammary carcinoma cells, MCF-7 human breast adenocarcinoma cell, Human Umbilical Vein Endothelial Cells (HUVECs)
Balb/c mice
Synthetic
doxorubicin (DOX)
Evidence 21 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, Endothelial cell
Homing
Prostate cancer
αvβ5 integrin, αvβ3 integrin, neuropilin-1

Source & Reference

TumorHoPe2.0
TumorHoPe2
pH-Switch Nanoprecipitation of Polymeric Nanoparticles for Multimodal Cancer Targeting and Intracellular Triggered Delivery of Doxorubicin
2016
Bárbara Herranz-Blanco et al. Adv Healthc Mater. 2016 Aug 5. Pages 1904-1916

Other

metastatic prostate cancer PC3MM2, human umbilical vein EA.hy 926 cells, primary rat liver and kidney cells, human red blood cells PC3MM2, EA.hy926 cells
Adult Wistar rats
IO-PNP-doxorubicin
Evidence 22 Activity

Activity

Tumor-homing Peptides

Target

Targeting
Hepatocellular carcinoma

Source & Reference

TumorHoPe2.0
TumorHoPe2
2016
Zhang Jinming et al. Nanomedicine. 2016 Mar 7. Pages 1303-1311

Other

HepG2 cells, normal human liver L02 cells
doxorubicin (DOX), sorafenib (SOR)
Evidence 23 Activity

Activity

Tumor-homing Peptides

Target

Tumor vessel
Targeting
Breast cancers
neuropilin-1 (NRP-1), αvβ3 and αvβ5 integrins

Source & Reference

TumorHoPe2.0
TumorHoPe2
Application of a proapoptotic peptide to intratumorally spreading cancer therapy
2012
Renwei Chen et al. Cancer Res. 2013 Feb 15 73(4):1352-61

Other

human embryonic kidney (HEK) 293T, prostate cancer PPC1, mouse breast cancer 4T1, Human tumor cell line M21, Human breast cancer cell line MCF-10CA1a, HTB-129 (MDA-MB-435S) line
Athymic nude mice, normal Balb/C mice
Synthetic
CDD (cell death domain)
Evidence 24 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, Endothelial cell, Tumor vessel
Homing
VEGF, neuropilin-1

Source & Reference

TumorHoPe2.0
TumorHoPe2
Tumor-penetrating peptides
2013
Tambet Teesalu et al. Front Oncol. 2013 Aug 27:3:216.

Other

Phage Display library
doxorubicin
Evidence 25 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
neuropilin-1

Source & Reference

TumorHoPe2.0
TumorHoPe2
iRGD-targeted delivery of a pro-apoptotic peptide activated by cathepsin B inhibits tumor growth and metastasis in mice
2016
Wang Qifan et al. Tumour Biol. 2016 Aug 37(8):10643-52.

Other

4T1 cancer cell line
Synthetic
procytotoxic peptide D(KLAKLAKKLAKLA)K-GG
Cyclic
Evidence 26 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, Tumor vessel
Homing
Hepatocellular carcinoma (HCC), Prostate cancer
Neuropilin-1 (NRP-1), αvβ3 integrins , αvβ5 integrins

Source & Reference

TumorHoPe2.0
TumorHoPe2
Tumour-specific activation of a tumour-blood transport improves the diagnostic accuracy of blood tumour markers in mice
2024
Christian Schmithals et al. EBioMedicine. 2024 Jul. 105 (105178).

Other

HepG2, Huh-7, LNCaP cells
6 weeks old male FVB/NHsd mice, Five weeks old male BL/6 mice
Synthetic
RGD control peptide (CRGDDGPKC), albumin-binding dye Evans blue
Evidence 27 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Targeting
Colon cancer
Alpha-5 beta -5 integrins

Source & Reference

TumorHoPe2.0
TumorHoPe2
Dual Effect of Chemo-PDT with Tumor Targeting Nanoparticles Containing iRGD Peptide
2023
Kim L G et al. Pharmaceutics. 2023 Feb 11 15(2):614.

Other

HCT116 cell line (Human colorectal carcinoma), HT29 cell line (Human colorectal adenocarcinoma)
Felmale athymic mice bearing HCT116 and HT29 cell lines
Synthetic
N-deacetylated PSA
Cyclic
Evidence 28 Activity

Activity

Tumor-homing Peptides

Target

Endothelial cell
Homing
Gastric cancer
Neuropilin-1

Source & Reference

TumorHoPe2.0
TumorHoPe2
Tumor-penetrating peptide fused to a pro-apoptotic peptide facilitates effective gastric cancer therapy
2017
Huang Y et al. Oncol Rep. 2017 Apr 37(4):2063-2070.

Other

MKN45, KATO III
5-6 weeks old male BALB/c nude mice, injected with MKN45 gastric cell lines
Synthetic
KLAKLAKKLAKLAK peptide, FITC
Cyclic
Evidence 29 Activity

Activity

Tumor-homing Peptides

Target

Tumor vessel
Homing
Peritoneal carcinomatosis
Neuropilin-1

Source & Reference

TumorHoPe2.0
TumorHoPe2
iRGD peptide conjugation potentiates intraperitoneal tumor delivery of paclitaxel with polymersomes
2016
Graciaa LS et al. Biomaterials . 2016 October 104: 247–257

Other

MKN-45P human gastric cancer cells, CT26 cell line, PPC-1, M21 cells
BALB/c nude mice
Synthetic
Alexa 488-conjugated goat anti-rabbit IgG, Alexa 647-conjugated goat anti-rat IgG
Evidence 30 Activity

Activity

Tumor-homing Peptides

Target

Homing
Neuropilin-1

Source & Reference

TumorHoPe2.0
TumorHoPe2
Tumor-Penetrating Delivery of siRNA against TNFα to Human Vestibular Schwannomas
2017
Ren Y et al. Sci Rep. 2017 Oct 10 7(1):12922

Other

Human vestibular schwannoma cell line HEI-193, Human ovarian cancer cell line OVCAR-8
Synthetic
Nuclease-free ddH2O
Evidence 31 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Prostate cancer

Source & Reference

TumorHoPe2.0
TumorHoPe2
Synthesis and activity of tumor-homing peptide iRGD and histone deacetylase inhibitor valproic acid conjugate
2014
Peng Z H et al. Bioorg Med Chem Lett. 2014 Apr 15 24(8):1928-33

Other

DU-145
Synthetic
Evidence 32 Activity

Activity

Tumor-homing Peptides

Target

Endothelial cell, Tumor Vascular cell
Targeting
Alpha -5 integrin, Neuropilin-1

Source & Reference

TumorHoPe2.0
TumorHoPe2
iRGD-coupled responsive fluorescent nanogel for targeted drug delivery
2013
Su S et al. Biomaterials. 2013 Apr 34(13):3523-33

Other

Vascular endothelial cell model(HUVEC), Tumor cell model(B16)
Synthetic
Doxorubicin, BSA
Evidence 33 Activity

Activity

Tumor-homing Peptides

Target

Homing
Human Melanoma

Source & Reference

TumorHoPe2.0
TumorHoPe2
Targeted nanoparticle-mediated LHPP for melanoma treatment
2019
Zhang Q et al. Int J Nanomedicine.2019 May 10:14:3455-3468

Other

B16-F10
6-8 weeks old Female C57BL/6 mice
Synthetic
C18-PEG-iRGD, DOTAP and mPEG-PLA
Evidence 34 Activity

Activity

Tumor-homing Peptides

Target

Penetrating
Alpha-5 beta-3 integrins, Alpha-5 beta-5 integrins

Source & Reference

TumorHoPe2.0
TumorHoPe2
Improved Anticancer Effect of Recombinant Protein izTRAIL Combined with Sorafenib and Peptide iRGD
2019
Fadeev R et al. Int J Mol Sci.2019 Jan 27 20(3):525

Other

Human fibrosarcoma cell line HT-1080
Male BALB/c nude mice
Synthetic
Sorafenib
Cell penetrating peptide, Cyclic
Evidence 35 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Targeting
integrin αvβ3

Source & Reference

TumorHoPe2.0
TumorHoPe2
Genetic Encoding of Targeted Magnetic Resonance Imaging Contrast Agents for Tumor Imaging
2020
Schuerle S et al. ACS Synth Biol. 2020 Feb 21 9(2):392-401.

Other

MDA-MB-231, MDA-MB-435S
Female nude mice bearing MDA-MB-453S flank tumors
Synthetic
mamC gene
Evidence 36 Activity

Activity

Tumor-homing Peptides

Target

Tumor vasculature, Tumor cell
Homing
integrin αvβ3, NRP-1

Source & Reference

TumorHoPe2.0
TumorHoPe2
Targeted Delivery of Dual Anticancer Drugs Based on Self-Assembled iRGD-Modified Soluble Drug-Polymer Pattern Conjugate Nanoparticles
2021
Li c et al. ACS Appl Bio Mater. 2021 Feb 15 4(2):1499-1507.

Other

LLC, B16
C57BL/6 mice
Synthetic
PEG, diosgenin (DGN),10-hydroxycamptothecin (HCPT)
Additional Detail Fields 5 fields
Iron oxide nanoworms, iRGD-linked abraxane diacylglycerols, dialkylglycerols Nanoworms(NWs), polyethylene glycol necrosis-inducing peptide, Fluorescein (FAM) nanoparticles, nanoworms, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)2000 DSPE-PEG2000-maleimide] hormone thymosin α1 (Tα1) MnO@mSiO2 nanoparticles 5-Fluorouracil, HPRP-A1 Superparamagnetic iron oxide nanoparticles (SPIO) 5-Fluorouracil (5-FU) IR780, Oxygen-loaded pH-sensitive fluorocarbon-functionalized nanoparticles (SFNs) Doxorubicin (DOX), sterically-stabilized liposome (SSL) Platinum nanoclusters (PN), PEG, G2 NH2 (amine-terminated dendrimer) Lipid nanoparticles, PI-3065, 7DW8-5 multistageresponsive nanoparticle (IDDHN) (Dendri Graft L Lysine, doxorubicin, indocyanine) doxorubicin (DOX) IO-PNP-doxorubicin doxorubicin (DOX), sorafenib (SOR) CDD (cell death domain) doxorubicin procytotoxic peptide D(KLAKLAKKLAKLA)K-GG RGD control peptide (CRGDDGPKC), albumin-binding dye Evans blue N-deacetylated PSA KLAKLAKKLAKLAK peptide, FITC Alexa 488-conjugated goat anti-rabbit IgG, Alexa 647-conjugated goat anti-rat IgG Nuclease-free ddH2O Doxorubicin, BSA C18-PEG-iRGD, DOTAP and mPEG-PLA Sorafenib mamC gene PEG, diosgenin (DGN),10-hydroxycamptothecin (HCPT)
CCSSCSSCC CCCCCSBSSSBSCCSSSCC
Cultured PPC1 human prostate cancer cells, M21 human melanoma cells 4T1 breast cancer cell line, MDA-MB-468 breast cancer cell line, 4306-ovarian cancer cell line, Lewis lung carcinoma (LLC) cells, hepatocellular carcinoma cells (CP20) Sp2/0, CHO (Chinese hamster ovary) K1, CHO DG44, PER.C6, W138, BHK, COS7, 293, HepG2, Huh7, 3T3, RIN, MDCK cell line PPC-1, PC-3, Du-145, 4T1, MIA PaCa-2, PDAC1.3, B16F10, M21, and MDA-MB-435 cell line B16F10 and H460 cells CT26 murine colorectal carcinoma cells, HT29 human colon cancer cells, L929 fibroblast cells Panc-1 human pancreatic cancer cells NCI-N87, SGC-7901, AGS, HGC27 gastric cancer cells, human immortalized gastric epithelial cell line(GES-1) 4T1 murine breast cancer cells B16-F10 murine melanoma cells MDA-MB-231 breast cancer cells 4T1 breast cancer cells, PDGF-driven glioma cells Mouse mammary breast tumor cell line (4T1), A2780 cell line 4T1 mammary carcinoma cells, MCF-7 human breast adenocarcinoma cell, Human Umbilical Vein Endothelial Cells (HUVECs) metastatic prostate cancer PC3MM2, human umbilical vein EA.hy 926 cells, primary rat liver and kidney cells, human red blood cells PC3MM2, EA.hy926 cells HepG2 cells, normal human liver L02 cells human embryonic kidney (HEK) 293T, prostate cancer PPC1, mouse breast cancer 4T1, Human tumor cell line M21, Human breast cancer cell line MCF-10CA1a, HTB-129 (MDA-MB-435S) line 4T1 cancer cell line HepG2, Huh-7, LNCaP cells HCT116 cell line (Human colorectal carcinoma), HT29 cell line (Human colorectal adenocarcinoma) MKN45, KATO III MKN-45P human gastric cancer cells, CT26 cell line, PPC-1, M21 cells Human vestibular schwannoma cell line HEI-193, Human ovarian cancer cell line OVCAR-8 DU-145 Vascular endothelial cell model(HUVEC), Tumor cell model(B16) B16-F10 Human fibrosarcoma cell line HT-1080 MDA-MB-231, MDA-MB-435S LLC, B16
Nude mice with multiple tumors (prostrate PC-3, PPC1, 22RVI Xenograft), (pancreatic MIAPaCa-2 Xenograft) BALB/c mice Athymic nude mice, ApoE null mice 6-week-old BalB/C mice BALB/c athymic nude mice Female BALB/c nude mice (5–6weeks old), C57BL/6 mice, ICR mice (7–8weeks old) Seven-week-old female inbred Balb/C mice Nude mice male BALB/c nude mice(4-week-old) BALB/c female mice (4−6 week old) Female BALB (Bagg Albino)/c nude mice weighing 20–25 g (5–6 weeks old), female C57BL/6 mice weighing 20–24 g (5–6 weeks old) Female BALB/cJ mice (4–6 weeks old) Female BALB/C mice (6 weeks old) Adult Wistar rats Athymic nude mice, normal Balb/C mice 6 weeks old male FVB/NHsd mice, Five weeks old male BL/6 mice Felmale athymic mice bearing HCT116 and HT29 cell lines 5-6 weeks old male BALB/c nude mice, injected with MKN45 gastric cell lines BALB/c nude mice 6-8 weeks old Female C57BL/6 mice Male BALB/c nude mice Female nude mice bearing MDA-MB-453S flank tumors C57BL/6 mice
T7 phage / CX7C peptide library T7 phage / cyclic Cx7C and linear X7 peptide library T7 phage display library