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Peptide record

TPDB40821

CRGDK CRGDK (conjugate 1a) Anticancer Cell-penetrating Peptides Tumor-homing Peptides standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB40821
CRGDK CRGDK (conjugate 1a)
Anticancer Cell-penetrating Peptides Tumor-homing Peptides
Cancer-related peptides Delivery and barrier-penetrating peptides
Peptipedia CPPsite3.0 PerseuCPP TumorHoPe2.0
standard
No
A 5-aa standard natural multi-activity (Anticancer, Cell-penetrating Peptides, and Tumor-homing Peptides) peptide sequence curated from Peptipedia, CPPsite3.0, PerseuCPP, and other sources, with an available 3D structural model.
Sequence
CRGDK
Physicochemical Analysis
C21H39N9O8S1
ANEQHILMFPSTWYV
RDCGK
577.66
8.97
2
1
0
+1
2.80
-1.960
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
1
R
0
N
1
D
1
C
0
E
0
Q
1
G
0
H
0
I
0
L
1
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 1 C: 1 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
5
C21H39N9O8S1
577.66
8.97
+1
2.80
-1.960
Free
L
Linear
Free
N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 3 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

human metastatic breast cancer cell line MDA-MB- 231, the aggressive human metastatic prostate cancer cell line PC3

Assay & Model

Nude mice bearing MDA-MB-231 tumors
Nude mice bearing MDA-MB-231 tumors

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Small molecule drug (Doxorubicin), DSPE- PEG2000
Lysosomes and Cytoplasm
Neuropilin-1 mediated
In vitro and in vivo
CCCCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

MDA-MB-231 Cell

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Synthetic
BF2-oxasmaragdyrin
Cytoplasm
In vitro
CCCCCCCSCC
Evidence 3 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, Tumor vessel
Targeting
Breast cancer
Neuropilin-1

Source & Reference

TumorHoPe2.0
TumorHoPe2
Tumor-Targeting Peptide for Redox-Responsive Pt Prodrug and Gene Codelivery and Synergistic Cancer Chemotherapy
2019
Bai Y et al. ACS Appl Bio Mater. 2019 Apr 15 2(4):1420-1426.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
MDA-MB-231, MDA-MB-231 and MCF-7
Female athymic BALB/c nude mice
Synthetic
Addition of BAplatin aqueous solution
Additional Detail Fields 4 fields
Addition of BAplatin aqueous solution
CCCCC CCCCCCCSCC
MDA-MB-231, MDA-MB-231 and MCF-7
Female athymic BALB/c nude mice