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Peptide record

TPDB40812

REA Anticancer Tumor-homing Peptides standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB40812
REA
Anticancer Tumor-homing Peptides
Cancer-related peptides
Peptipedia StackTHP StackTHPred TumorHoPe2.0
standard
No
A 9-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.
Sequence
CREAGRKAC
Physicochemical Analysis
C37H68N16O12S2
NDQHILMFPSTWYV
ARC
993.17
9.15
3
1
2
+2
3.82
-0.911
22.22
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
125
12.59
2
Residue Composition
number
2
A
2
R
0
N
0
D
2
C
1
E
0
Q
1
G
0
H
0
I
0
L
1
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 2 N: 0 D: 0 C: 2 E: 1 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
9
C37H68N16O12S2
993.17
9.15
+2
3.82
-0.911
Evidence Records 2 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Lymphatic vessel
Homing
Prostrate cancer
Podoplanin

Source & Reference

TumorHoPe2.0
TumorHoPe2
Lymphatic zip codes in premalignant lesions and tumors
2006
Zhang L et al. Cancer Res. 2006 Jun 1 66(11):5696-706.
US 2007/0219134A1

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
MDA-MB-435 human breast cancer cell line
TRAMP mice, Nude mice bearing xenogragt from the human prostate cancer cell lines PPC1, M12, DU145, and LNCaP
Phage display library
T7 phage/CX7C peptide library
Radioactive indium, proapoptotic peptide
Evidence 2 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Lung cancer, Breast cancer, Liver cancer, Melanoma, stomach cancer, Pancreatic cancer, Colorectal cancer, Ovarian cancer, Renal cell carcinoma, Prostate cancer, Brain tumor

Source & Reference

TumorHoPe2.0
TumorHoPe2
Noxa-derived, cell death-inducing peptide eMTD
2022
US 11248024 B2
US 11248024 B2

Other

Sp2/0, CHO (Chinese hamster ovary) K1, CHO DG44, PER.C6, W138, BHK, COS7, 293, HepG2, Huh7, 3T3, RIN, MDCK cell line
6-week-old BalB/C mice
Synthetic
necrosis-inducing peptide, Fluorescein (FAM)
Additional Detail Fields 4 fields
Radioactive indium, proapoptotic peptide necrosis-inducing peptide, Fluorescein (FAM)
MDA-MB-435 human breast cancer cell line Sp2/0, CHO (Chinese hamster ovary) K1, CHO DG44, PER.C6, W138, BHK, COS7, 293, HepG2, Huh7, 3T3, RIN, MDCK cell line
TRAMP mice, Nude mice bearing xenogragt from the human prostate cancer cell lines PPC1, M12, DU145, and LNCaP 6-week-old BalB/C mice
T7 phage/CX7C peptide library