TPDB

3D PDB MODEL

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TPDB ID TPDB40789

Activity

Anticancer Tumor-homing Peptides

Activity_category_statistics

Cancer-related peptides

Database_Source

Peptipedia StackTHP StackTHPred TumorHoPe2.0

Sequence_Type

standard

Has_Modification No

Description A 9-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.

Sequence

CNRRTKAGC

FASTA

>TPDB40789|Anticancer;Tumor-homing Peptides|length=9
CNRRTKAGC

Formula C37H69N17O12S2

Absent Amino Acids DEQHILMFPSWYV

Common Amino Acids RC

Mass 1008.18

PI 10.12

Basic Residues 3

Acidic Residues 0

Hydrophobic Residues 1

Net Charge +3

Boman Index 2.53

Hydrophobicity -1.189

Aliphatic Index 11.11

Half Life

Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 125

Absorbance 280nm 12.40

Polar Residues 4

number

1

A

2

R

1

N

0

D

2

C

0

E

0

Q

1

G

0

H

0

I

0

L

1

K

0

M

0

F

0

P

0

S

1

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 1 R: 2 N: 1 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 0

Length

9

Formula

C37H69N17O12S2

Mass

1008.18

PI

10.12

Net Charge

+3

Boman Index

2.53

Hydrophobicity

-1.189

Motif

CendR

Evidence 1 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Tumor vessel

Homing or Targeting Homing

Target Tumor Esophagus and gastroesophageal cancer

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title Screening of specific binding peptide targeting blood vessel of human esophageal cancer in vivo in mice

Year 2002

Reference

Zhi M et al. Chin Med J (Engl). 2011 Feb 124(4):581-5.

Other

Source Activity Label	Source Definition
Tumor-homing Peptides	TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.

InVivo Model

2-month-old Balb/c mice with human esophageal tumor xenograft, fresh human esophageal cancer tissue in immunosuppressed Balb/c mice

Source Type Phage display library

Phage Display Library M13 phage/C7C peptide library

Evidence 2 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Tumor cell, Tumor vessel, Tumor stem cell, Endothelial cell,

Homing or Targeting Homing

Receptors Biomarker gC1q/p32 receptor

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title Targeted delivery system and methods of use therefor

Year 2022

Reference

US 11512110 B2

Patent US 11512110 B2

Other

InVivo Model Athymic nude mice, ApoE null mice

Source Type Phage display library

Phage Display Library T7 phage / cyclic Cx7C and linear X7 peptide library

Conjugate Payload Nanoworms(NWs), polyethylene glycol

Evidence 3 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Tumor cell, Tumor vessel, Tumor stem cell, Endothelial cell,

Homing or Targeting Homing

Receptors Biomarker gC1q/p32 receptor

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title Targeted delivery system and methods of use therefor

Year 2022

Reference

US 11512110 B2

Patent US 11512110 B2

Other

InVivo Model Athymic nude mice, ApoE null mice

Source Type Phage display library

Phage Display Library T7 phage / cyclic Cx7C and linear X7 peptide library

Conjugate Payload Nanoworms(NWs), polyethylene glycol

Conjugate_Payload

Nanoworms(NWs), polyethylene glycol

InVivo_Model

2-month-old Balb/c mice with human esophageal tumor xenograft, fresh human esophageal cancer tissue in immunosuppressed Balb/c mice Athymic nude mice, ApoE null mice

Phage_Display_Library

M13 phage/C7C peptide library T7 phage / cyclic Cx7C and linear X7 peptide library