Back to search

Peptide record

TPDB40786

NGR peptide Anticancer Tumor-homing Peptides standard
13 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB40786
NGR peptide
Anticancer Tumor-homing Peptides
Cancer-related peptides
Peptipedia StackTHP StackTHPred TumorHoPe2.0
standard
No
A 13-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.
Sequence
CNGRCVSGCAGRC
Physicochemical Analysis
C45H80N20O16S4
DEQHILKMFPTWY
C
1285.49
8.31
2
0
2
+2
1.14
0.115
30.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
250
19.45
6
Residue Composition
number
1
A
2
R
1
N
0
D
4
C
0
E
0
Q
3
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 2 N: 1 D: 0 C: 4 E: 0 Q: 0 G: 3 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
13
C45H80N20O16S4
1285.49
8.31
+2
1.14
0.115
NGR
Evidence Records 6 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Targeting
Hepatic and pancreatic cancer
Integrins

Source & Reference

TumorHoPe2.0
TumorHoPe2
Potential tumor-targeting peptide vector of histidylated oligolysine conjugated to a tumor-homing RGD motif
2001
Aoki Y et al. Cancer Gene Ther. 2001 Oct 8(10):783-7.
WO06067633A2

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
Human hepatoma cell lines ( PLC / PRF / 5 andHepG2 ) ,human pancreatic cancer cell lines ( Hs700T and MIAPaCa - 2 )
Phage display library
Evidence 2 Activity

Activity

Tumor-homing Peptides

Target

Homing
Breast cancer

Source & Reference

TumorHoPe2.0
TumorHoPe2
Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis
2000
Pasqualini R et al. Cancer Res. 2000 Feb 1 60(3):722-7.
WO06067633A2

Other

MDA-MB-435 breast cancer cells transfected with APN cDNA.
Mice bearing MDA-MB-435 tumors
Phage display library
M13 phage /CX3CX3CX3C peptide library
Doxorubicin
Evidence 3 Activity

Activity

Tumor-homing Peptides

Target

Endothelial cell
Homing
Human breast carcinoma
Integrin

Source & Reference

TumorHoPe2.0
TumorHoPe2
Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model
1999
Arap W et al. Science. 1998 Jan 16 279(5349):377-80.
WO06067633A2

Other

Mice bearing MDA-MB-derived tumors, SLK derived human Kaposi's sarcoma xenografts
Phage display library
M13 Phage/CX3CX3CX3C peptide library
Evidence 4 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Lung cancer, Breast cancer, Liver cancer, Melanoma, stomach cancer, Pancreatic cancer, Colorectal cancer, Ovarian cancer, Renal cell carcinoma, Prostate cancer, Brain tumor

Source & Reference

TumorHoPe2.0
TumorHoPe2
Noxa-derived, cell death-inducing peptide eMTD
2022
US 11248024 B2
US 11248024 B2

Other

Sp2/0, CHO (Chinese hamster ovary) K1, CHO DG44, PER.C6, W138, BHK, COS7, 293, HepG2, Huh7, 3T3, RIN, MDCK cell line
6-week-old BalB/C mice
Synthetic
necrosis-inducing peptide, Fluorescein (FAM)
Evidence 5 Activity

Activity

Tumor-homing Peptides

Target

Tumor vasculature
Targeting
Aminopeptidase N

Source & Reference

TumorHoPe2.0
TumorHoPe2
Protease inhibitor:protease sensitive expression system, composition and methods for improving the therapeutic activity and specificity of proteins delivered by bacteria
2022
US 11219671 B1
US 11219671 B1

Other

Salmonella typhimurium
Phage display library
Ph.D-7 Phage Display
Evidence 6 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, Tumor vessel, Tumor stem cell, Endothelial cell, Epithelial cell, Dendritic cell
Homing

Source & Reference

TumorHoPe2.0
TumorHoPe2
Methods and compositions using peptides and proteins with C-terminal elements
2019
US 10370245 B2
US 10370245 B2

Other

PPC-1, PC-3, Du-145, 4T1, MIA PaCa-2, PDAC1.3, B16F10, M21, and MDA-MB-435 cell line
BALB/c athymic nude mice
Phage Display library
T7 phage display library
nanoparticles, nanoworms, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)2000 DSPE-PEG2000-maleimide]
Additional Detail Fields 4 fields
Doxorubicin necrosis-inducing peptide, Fluorescein (FAM) nanoparticles, nanoworms, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)2000 DSPE-PEG2000-maleimide]
Human hepatoma cell lines ( PLC / PRF / 5 andHepG2 ) ,human pancreatic cancer cell lines ( Hs700T and MIAPaCa - 2 ) MDA-MB-435 breast cancer cells transfected with APN cDNA. Sp2/0, CHO (Chinese hamster ovary) K1, CHO DG44, PER.C6, W138, BHK, COS7, 293, HepG2, Huh7, 3T3, RIN, MDCK cell line PPC-1, PC-3, Du-145, 4T1, MIA PaCa-2, PDAC1.3, B16F10, M21, and MDA-MB-435 cell line
Mice bearing MDA-MB-435 tumors Mice bearing MDA-MB-derived tumors, SLK derived human Kaposi's sarcoma xenografts 6-week-old BalB/C mice Salmonella typhimurium BALB/c athymic nude mice
M13 phage /CX3CX3CX3C peptide library M13 Phage/CX3CX3CX3C peptide library Ph.D-7 Phage Display T7 phage display library